	US 12,419,974 B2
	Imaging composition comprising porous silicon micro-particles
Dokyoung Kim, Seoul (KR); and Jaehoon Kim, Seoul (KR)
Assigned to UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY, Gyeonggi-Do (KR)
Filed by UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY, Gyeonggi-do (KR)
Filed on Jul. 1, 2021, as Appl. No. 17/365,134.
Claims priority of application No. 10-2020-0053855 (KR), filed on May 6, 2020.
Prior Publication US 2022/0031868 A1, Feb. 3, 2022
Int. Cl. A61K 49/00 (2006.01); A61B 6/00 (2024.01); A61B 6/03 (2006.01); B82Y 5/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01); C01G 5/00 (2006.01)

CPC A61K 49/0093 (2013.01) [A61B 6/032 (2013.01); A61B 6/481 (2013.01); C01G 5/00 (2013.01); B82Y 5/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); C01P 2004/03 (2013.01)]

6 Claims

1. A composition for imaging of biological tissue by computed tomography (CT), comprising a composite in which oxidized porous silicon microparticles and silver nanoparticles are combined,

wherein the silver nanoparticles are bonded into pores of the oxidized porous silicon microparticles and attached to a surface of the oxidized porous silicon microparticles,

wherein the composite is dissolved in a mixture of glycerol and water in a ratio of 3:1,

wherein the composition has in vivo local area reactivity,

wherein a size of the porous silicon microparticles is in a range of 1 μm to 10 μm, and

wherein the composite includes elemental silicon, elemental oxygen, and elemental silver in a weight ratio of 100:100 to 120:15 to 30.