US 12,419,967 B2
Polyinosinic—polycytidylic acid compositions and methods of making same
Mercedes Pozuelo Rubio, Valencia (ES); Marisol Quintero Ortiz, Valencia (ES); and Ana Villanueva Garcia, Valencia (ES)
Assigned to HIGHLIGHT THERAPEUTICS, S.L., Valencia (ES)
Filed by HIGHLIGHT THERAPEUTICS, S.L., Valencia (ES)
Filed on Nov. 17, 2022, as Appl. No. 17/989,526.
Application 16/724,519 is a division of application No. 15/753,328, granted, now 10,568,971, issued on Feb. 25, 2020, previously published as PCT/EP2016/078078, filed on Nov. 17, 2016.
Application 17/989,526 is a continuation of application No. 17/095,059, filed on Nov. 11, 2020, granted, now 11,896,606.
Application 17/095,059 is a continuation of application No. 16/724,519, filed on Dec. 23, 2019, granted, now 10,869,881, issued on Dec. 22, 2020.
Claims priority of application No. 15194864 (EP), filed on Nov. 17, 2015.
Prior Publication US 2023/0116048 A1, Apr. 13, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/69 (2017.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/19 (2006.01); A61K 31/15 (2006.01); A61K 31/713 (2006.01); A61K 31/74 (2006.01); A61K 47/26 (2006.01); A61K 47/50 (2017.01); C07K 16/28 (2006.01)
CPC A61K 47/6935 (2017.08) [A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 9/19 (2013.01); A61K 31/15 (2013.01); A61K 31/713 (2013.01); A61K 31/74 (2013.01); A61K 47/26 (2013.01); A61K 47/50 (2017.08); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01)] 16 Claims
 
1. Polyinosinic-polycytidylic acid [poly(I:C)] molecules, or a salt and/or solvate thereof, comprising double-stranded polynucleotides formed by annealing together respective single-stranded poly(I) and poly(C) molecules, wherein
(a) at least 40% of the double-stranded polyribonucleotides comprise at least 850 base pairs, and
(b) at least 50% of the double-stranded polyribonucleotides comprise between 400 and 5000 base pairs.