US 12,419,964 B2
Antibody drug conjugate (ADC) targeting Nectin 4 and comprising an exatecan payload
Jacobus Petrus Maria Elands, Forest (BE); Joanna Fares, Aix-en-Provence (FR); Guy Fournet, Lyons (FR); Benoit Joseph, Villeurbanne (FR); Florence Lhospice, Bretagne (FR); Marc Lopez, Marseilles (FR); Daniel Olive, Marseilles (FR); Xavier Preville, Roquefort les Pins (FR); and Warren Viricel, Sainte Consorce (FR)
Assigned to ELI LILLY AND COMPANY, Indianapolis, IN (US); UNIVERSITÉ D'AIX-MARSEILLE, Marseilles (FR); INSERM (Institut National De La Sante Et De La Recherche Medicale), Paris (FR); INSTITUT JEAN PAOLI & IRENE CALMETTES, Marseilles (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Paris (FR); MABLINK BIOSCIENCE, Lyons (FR); and UNIVERSITE CLAUDE BERNARD LYON, Villeurbanne (FR)
Filed by ELI LILLY AND COMPANY, Indianapolis, IN (US); UNIVERSITÉ D'AIX-MARSEILLE, Marseilles (FR); INSERM (Institut National De La Sante Et De La Recherche Medicale), Paris (FR); INSTITUT JEAN PAOLI & IRENE CALMETTES, Marseilles (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Paris (FR); MABLINK BIOSCIENCE, Lyons (FR); and UNIVERSITE CLAUDE BERNARD LYON, Villeurbanne (FR)
Filed on Oct. 2, 2024, as Appl. No. 18/904,628.
Claims priority of application No. 23201214 (EP), filed on Oct. 2, 2023.
Prior Publication US 2025/0127916 A1, Apr. 24, 2025
Int. Cl. A61K 47/68 (2017.01); A61P 35/00 (2006.01)
CPC A61K 47/68037 (2023.08) [A61K 47/6849 (2017.08); A61K 47/6889 (2017.08); A61P 35/00 (2018.01)] 11 Claims
OG exemplary drawing
 
1. An antibody-drug conjugate (ADC) of the formula:

OG Complex Work Unit Chemistry
wherein:
Ab is an antibody that binds human Nectin-4 and comprises a heavy chain (HC) and a light chain (LC), wherein:
Ab comprises a HC of SEQ ID NO:5 and a LC of SEQ ID NO:6, DAR is 8, and the Ab is conjugated via cysteines at positions C222, C228, C231 of the HC and via a cysteine of C214 of the LC.