US 12,419,945 B2
Vaccines against Zika virus
David Weiner, Merion, PA (US); and Kar Muthumani, Cherry Hill, NJ (US)
Assigned to The Wistar Institute of Anatomy and Biology, Philadelphia, PA (US); and The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed by The Trustees of the University of Pennsylvania, Philadelphia, PA (US); and The Wistar Institute of Anatomy and Biology, Philadelphia, PA (US)
Filed on May 16, 2023, as Appl. No. 18/318,061.
Application 18/318,061 is a continuation of application No. 16/078,270, granted, now 11,648,303, previously published as PCT/US2017/019407, filed on Feb. 24, 2017.
Claims priority of provisional application 62/462,249, filed on Feb. 22, 2017.
Claims priority of provisional application 62/417,100, filed on Nov. 3, 2016.
Claims priority of provisional application 62/396,742, filed on Sep. 19, 2016.
Claims priority of provisional application 62/305,183, filed on Mar. 8, 2016.
Claims priority of provisional application 62/300,030, filed on Feb. 25, 2016.
Prior Publication US 2024/0115689 A1, Apr. 11, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/12 (2006.01); A61K 39/00 (2006.01); C07K 14/18 (2006.01); C07K 14/54 (2006.01); C12N 7/00 (2006.01)
CPC A61K 39/12 (2013.01) [C07K 14/1816 (2013.01); C12N 7/00 (2013.01); A61K 2039/53 (2013.01); C07K 14/54 (2013.01); C07K 2319/02 (2013.01); C12N 2770/24034 (2013.01)] 17 Claims
 
1. A synthetic consensus Zika antigen, wherein the amino acid of the synthetic consensus Zika antigen is selected from the group consisting of:
SEQ ID NO:1, an amino acid sequence that is at least 97% homologous to SEQ ID NO:1, a fragment of SEQ ID NO:1 lacking an IgE signal peptide, an amino acid sequence that is at least 97% homologous to a fragment of SEQ ID NO:1 lacking an IgE signal peptide,
SEQ ID NO:3, an amino acid sequence that is at least 98% homologous to SEQ ID NO:3, a fragment of SEQ ID NO:3 lacking an IgE signal peptide, an amino acid sequence that is at least 98% homologous to a fragment of SEQ ID NO:3 lacking an IgE signal peptide,
SEQ ID NO:5, an amino acid sequence that is at least 95% homologous to SEQ ID NO:5, a fragment of SEQ ID NO:5 lacking an IgE signal peptide, an amino acid sequence that is at least 95% homologous to a fragment of SEQ ID NO:5 lacking an IgE signal peptide,
SEQ ID NO:7, an amino acid sequence that is at least 90% homologous to SEQ ID NO:7, a fragment of SEQ ID NO:7 lacking an IgE signal peptide, and an amino acid sequence that is at least 90% homologous to a fragment of SEQ ID NO:7 lacking an IgE signal peptide.