US 12,419,906 B2
Compositions and methods for application over skin
Ariya Akthakul, Boston, MA (US); Nithin Ramadurai, Wakefield, MA (US); Amir Nashat, Boston, MA (US); Daniela Beccati, Watertown, MA (US); and Melaney Bouthillette, Newton, MA (US)
Assigned to Shiseido Company, Limited, Tokyo (JP)
Filed by Shiseido Company, Limited, Tokyo (JP)
Filed on Jan. 8, 2021, as Appl. No. 17/144,379.
Application 17/144,379 is a continuation of application No. 15/774,350, granted, now 11,160,827, previously published as PCT/US2016/061150, filed on Nov. 9, 2016.
Claims priority of provisional application 62/252,903, filed on Nov. 9, 2015.
Prior Publication US 2021/0213047 A1, Jul. 15, 2021
Int. Cl. A61K 31/80 (2006.01); A61K 9/00 (2006.01); A61K 9/70 (2006.01); A61K 31/573 (2006.01); A61K 31/58 (2006.01); A61L 26/00 (2006.01)
CPC A61K 31/80 (2013.01) [A61K 9/0014 (2013.01); A61K 9/7015 (2013.01); A61K 31/573 (2013.01); A61K 31/58 (2013.01); A61L 26/0019 (2013.01); A61L 26/0061 (2013.01)] 17 Claims
 
1. A composition for in-situ formation of a layer over the skin of a subject, wherein said composition is a two-part composition comprising a first and a second part;
wherein said first part has a viscosity above 100 cP at about 25° C. and comprises as ingredients:
Polymer A, which is vinyl terminated polydimethylsiloxane having an average molecular weight above about 72,000 Da and below about 200,000 Da;
Polymer B, which is hydride terminated polydimethylsiloxane having an average molecular weight between about 2,200 and about 6,000 Da;
wherein said first part comprises about 50 to about 90% by weight of Polymer A, about 5 to about 30% by weight of Polymer B, and about 5 to about 15% by weight of a reinforcing component;
wherein said second part has a viscosity above about 100 cP at about 25° C. and comprises a catalyst that facilitates crosslinking of the Polymer A and Polymer B;
wherein said second part further comprises Polymer C, which is vinyl terminated polydimethylsiloxane having an average molecular weight below 17,500 Da; and
wherein said reinforcing component has particle size of from about 2 nm to about 1000 nm.