US 12,419,905 B2
Methods and compositions for the treatment of amyloid-related disorders
Stephen M. Strittmatter, Durham, CT (US); Erik Christian Gunther, Branford, CT (US); and Levi M. Smith, Branford, CT (US)
Assigned to YALE UNIVERSITY, New Haven, CT (US)
Appl. No. 17/258,357
Filed by YALE UNIVERSITY, New Haven, CT (US)
PCT Filed Jul. 3, 2019, PCT No. PCT/US2019/040565
§ 371(c)(1), (2) Date Jan. 6, 2021,
PCT Pub. No. WO2020/010236, PCT Pub. Date Jan. 9, 2020.
Claims priority of provisional application 62/694,710, filed on Jul. 6, 2018.
Prior Publication US 2021/0268016 A1, Sep. 2, 2021
Int. Cl. A61K 31/795 (2006.01); A61K 31/155 (2006.01); A61K 31/195 (2006.01); A61K 31/198 (2006.01); A61K 31/64 (2006.01); A61K 31/78 (2006.01); A61K 31/785 (2006.01); A61K 31/787 (2006.01); A61K 31/80 (2006.01); A61K 36/16 (2006.01); A61K 38/26 (2006.01); A61K 38/28 (2006.01); A61K 45/06 (2006.01); A61P 25/28 (2006.01)
CPC A61K 31/795 (2013.01) [A61K 31/155 (2013.01); A61K 31/195 (2013.01); A61K 31/198 (2013.01); A61K 31/64 (2013.01); A61K 31/78 (2013.01); A61K 31/785 (2013.01); A61K 31/787 (2013.01); A61K 31/80 (2013.01); A61K 36/16 (2013.01); A61K 38/26 (2013.01); A61K 38/28 (2013.01); A61K 45/06 (2013.01); A61P 25/28 (2018.01)] 19 Claims
 
1. A method of treating an amyloid-related disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an anionic polymer, or a pharmaceutically acceptable salt thereof, wherein the anionic polymer comprises poly (4-styrenesulfonic acid-co-maleic acid), or the sodium salt thereof.