US 12,419,878 B2
Sustained release local anesthetic hydrogel composition
Molly Shoichet, York (CA); Michael J. Cooke, Toronto (CA); and Sonja Ing, Toronto (CA)
Assigned to The Governing Council of the University of Toronto, Toronto (CA)
Appl. No. 17/595,470
Filed by THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, Toronto (CA)
PCT Filed May 18, 2020, PCT No. PCT/CA2020/050666
§ 371(c)(1), (2) Date Nov. 17, 2021,
PCT Pub. No. WO2020/232539, PCT Pub. Date Nov. 26, 2020.
Claims priority of provisional application 62/849,671, filed on May 17, 2019.
Prior Publication US 2022/0202793 A1, Jun. 30, 2022
Int. Cl. A61K 31/445 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/167 (2006.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); A61P 23/02 (2006.01)
CPC A61K 31/445 (2013.01) [A61K 9/0024 (2013.01); A61K 9/06 (2013.01); A61K 31/167 (2013.01); A61K 47/36 (2013.01); A61K 47/38 (2013.01); A61P 23/02 (2018.01)] 28 Claims
OG exemplary drawing
 
1. A pharmaceutical composition comprising: 1.8 wt % to 3 wt % methylcellulose and 0.1 wt % to 3 wt % hyaluronan in the form of a gel polymer matrix, and at least one local anesthetic agent.