US 12,419,824 B2
Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes
Mauricio Valerio Santiago, Cadiz (ES); Consuelo García Hernández, Murcia (ES); Núria Almiñana Doménech, Barcelona (ES); and Albert Soley Astals, Barcelona (ES)
Assigned to Lubrizol Advanced Materials, Inc., Cleveland, OH (US)
Appl. No. 17/427,364
Filed by Lubrizol Advanced Materials, Inc., Cleveland, OH (US)
PCT Filed Feb. 10, 2020, PCT No. PCT/IB2020/051021
§ 371(c)(1), (2) Date Jul. 30, 2021,
PCT Pub. No. WO2020/161683, PCT Pub. Date Aug. 13, 2020.
Claims priority of application No. 19382092 (EP), filed on Feb. 8, 2019.
Prior Publication US 2022/0183950 A1, Jun. 16, 2022
Int. Cl. A61K 38/00 (2006.01); A61K 8/64 (2006.01); A61Q 19/06 (2006.01); A61Q 19/08 (2006.01); C07K 5/113 (2006.01); C07K 7/06 (2006.01)
CPC A61K 8/64 (2013.01) [A61Q 19/06 (2013.01); A61Q 19/08 (2013.01); C07K 5/1021 (2013.01); C07K 7/06 (2013.01); A61K 38/00 (2013.01)] 8 Claims
 
1. A compound selected from the group consisting of:
 
 (R1-[SEQ ID NO. 1]-R2)
 
 R1-Asp-Val-Tyr-Lys-R2;
 
 
 
 (R1-[SEQ ID NO. 2]-R2)
 
 R1-Ala-Leu-Lys-Pro-Asn-Thr-R2;
 
 
 
 (R1-[SEQ ID NO. 3]-R2)
 
 R1-Glu-Val-Tyr-Lys-R2;
 
 
 
 (R1-[SEQ ID NO. 4]-R2)
 
 R1-Asp-Ile-Tyr-Lys-R2;
 
 
 
 (R1-[SEQ ID NO. 5]-R2)
 
 R1-Asp-Val-Phe-Lys-R2;
 
 
 
 (R1-[SEQ ID NO. 6]-R2)
 
 R1-Asp-Val-Tyr-Arg-R2;
 
 
 
 (R1-[SEQ ID NO. 7]-R2)
 
 R1-Asn-Val-Tyr-Lys-R2;
 
 
 
 (R1-[SEQ ID NO. 8]-R2)
 
 R1-Asp-Leu-Tyr-Lys-R2;
 
 
 
 (R1-[SEQ ID NO. 9]-R2)
 
 R1-Ala-Asp-Val-Tyr-Lys-R2;
 
 
 
 (R1-[SEQ ID NO. 10]-R2)
 
 R1-Asp-Val-Tyr-Lys-Ala-R2;
 
 
 
 (R1-[SEQ ID NO. 15]-R2)
 
 R1-Glu-Ile-Tyr-Lys-R2;
 
 
 
 (R1-[SEQ ID NO. 18]-R2)
 
 R1-Glu-Ile-Tyr-Arg-R2;
 
 
 
 (R1-[SEQ ID NO. 19]-R2)
 
 R1-Glu-Ile-Phe-Arg-R2;
 
 
 
 (R1-[SEQ ID NO. 22]-R2)
 
 R1-Ala-Leu-Arg-Pro-Asn-Thr-R2;
 
 
 
 (R1-[SEQ ID NO. 23]-R2)
 
 R1-Ala-Leu-Lys-Val-Asn-Thr-R2;
 
 
 
 (R1-[SEQ ID NO. 30]-R2)
 
 R1-Leu-Lys-Pro-Asn-Thr-R2;
 
 
 
 (R1-[SEQ ID NO. 31]-R2)
 
 R1-Ala-Leu-Lys-Pro-Asn-R2;
 
 
 
 (R1-[SEQ ID NO. 32]-R2)
 
 R1-Gly-Ile-Lys-Pro-Asn-Thr-R2;
 
 
 
 (R1-[SEQ ID NO. 34]-R2)
 
 R1-Ala-Ile-Arg-Pro-Asn-Thr-R2;
 
 
 
 (R1-[SEQ ID NO. 34]-R2)
 
 R1-Gly-Val-Arg-Pro-Asn-Thr-R2;
 
 
 
 (R1-[SEQ ID NO. 40]-R2)
 
 R1-Ala-Leu-Lys-Pro-Gln-Thr-R2;
and combinations thereof;
wherein R1 is selected from the group consisting of H, a polymer derived from polyethylene glycol, a non-cyclic aliphatic group, alicyclyl, heterocyclyl, heteroarylalkyl, aryl, aralkyl and R5—CO—, wherein R5 is selected from the group consisting of H, a non-cyclic aliphatic group, alicyclyl, aryl, aralkyl, heterocyclyl and heteroarylalkyl;
R2 is selected from the group consisting of —NR3R4, —OR3, —SR3, wherein R3 and R4 are independently selected from a group consisting of H, a polymer derived from polyethylene glycol, a non-cyclic aliphatic group, alicyclyl, heterocyclyl, heteroarylalkyl, aryl and aralkyl; and
R1 and R2 are not amino acids.