US 12,419,622 B2
Localized fusion of native leaflets using activated adhesive
Hengchu Cao, Irvine, CA (US); Shih-Hwa Shen, Irvine, CA (US); Holly Kung Jung Hsu, Irvine, CA (US); and Krystal Ya-Fong Lai, Irvine, CA (US)
Assigned to EDWARDS LIFESCIENCES CORPORATION, Irvine, CA (US)
Filed by EDWARDS LIFESCIENCES CORPORATION, Irvine, CA (US)
Filed on Sep. 27, 2023, as Appl. No. 18/476,253.
Application 18/476,253 is a continuation of application No. 16/850,950, filed on Apr. 16, 2020, granted, now 11,806,001, issued on Nov. 7, 2023.
Application 16/850,950 is a continuation of application No. PCT/US2018/056016, filed on Oct. 16, 2018.
Claims priority of provisional application 62/575,252, filed on Oct. 20, 2017.
Prior Publication US 2025/0099090 A1, Mar. 27, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 17/00 (2006.01); A61B 17/08 (2006.01); A61F 2/24 (2006.01); A61F 2/90 (2013.01)
CPC A61B 17/00491 (2013.01) [A61F 2/246 (2013.01); A61F 2/90 (2013.01); A61B 2017/00243 (2013.01); A61B 2017/00292 (2013.01); A61B 2017/00495 (2013.01); A61B 2017/005 (2013.01); A61B 2017/00504 (2013.01); A61B 2017/00522 (2013.01); A61B 2017/00557 (2013.01); A61B 2017/081 (2013.01); A61F 2/2442 (2013.01); A61F 2/2445 (2013.01); A61F 2/2466 (2013.01); A61F 2250/0059 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A transcatheter applicator system for application of an adhesive between native leaflets for localized fusion thereof, the transcatheter system comprising:
a delivery catheter comprising a capsule at the distal end of the delivery catheter, wherein the capsule comprises a cartridge or is in connection with a cartridge, wherein the cartridge comprises an adhesive therein;
an applicator for dispensing an adhesive, wherein the applicator protrudes from an outer surface of the capsule and is configured to dispense adhesive from the cartridge;
one or more capture features in connection with the capsule, wherein the one or more capture features are configured for capturing two or more native leaflets such that the applicator can dispense adhesive between the two or more native leaflets when captured by the one or more capture features; and
one or more curing elements in connection with the capsule, the one or more curing elements configured to cure the adhesive after the adhesive has been dispensed upon native leaflets.