| CPC A61B 6/504 (2013.01) [A61B 6/481 (2013.01); A61B 6/5258 (2013.01); G06T 7/00 (2013.01); G06T 2207/10116 (2013.01)] | 15 Claims |

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1. A device for digital subtraction imaging, the device comprising:
a processor configured to
receive 3D image data of a region of interest of an object, wherein the 3D image data comprises a 3D representation of the object that is based on a reconstruction from a plurality of 2D projection images of the region of interest;
receive a 2D live X-ray image of the region of interest;
register the 3D image data and the 2D live X-ray image, wherein a matching pose of the 3D image data corresponding to the 2D live X-ray image is determined to compute a digitally reconstructed radiography from the 3D image data based on the determined matching pose to generate a 2D mask image and to use, for the generating of the 2D mask image, current data related to the 2D live X-ray image to achieve an adapted 2D mask image, wherein the data related to the 2D live X-ray image comprises at least one of 2D live acquisition parameters or data of the 2D live X-ray image;
subtract the generated adapted 2D mask image from the 2D live X-ray image; and
provide a digital image highlighting changes in the region of interest.
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