US 12,419,313 B2
Campylobacter bacteriophages and uses thereof
Alexander Sulakvelidze, Brookeville, MD (US)
Assigned to INTRALYTIX, INC., Columbia, MD (US)
Filed by Intralytix, Inc., Columbia, MD (US)
Filed on Dec. 21, 2021, as Appl. No. 17/645,423.
Claims priority of provisional application 63/128,634, filed on Dec. 21, 2020.
Prior Publication US 2022/0264896 A1, Aug. 25, 2022
Int. Cl. A01N 63/40 (2020.01); A23B 2/783 (2025.01); A23B 4/22 (2006.01); A23L 3/3571 (2006.01); A23L 33/135 (2016.01); A61K 35/745 (2015.01); A61K 35/747 (2015.01); A61K 35/76 (2015.01); A61K 39/00 (2006.01)
CPC A01N 63/40 (2020.01) [A23B 2/783 (2025.01); A23B 4/22 (2013.01); A23L 33/135 (2016.08); A61K 35/745 (2013.01); A61K 35/747 (2013.01); A61K 35/76 (2013.01); A61K 39/00 (2013.01)] 25 Claims
 
1. A dietary supplement and/or nutraceutical composition comprising one or more of an isolated bacteriophage CJLB-4 deposited under ATCC Deposit Accession No. PTA-126839, CJLB-5 deposited under ATCC Deposit Accession No. PTA-126840, CJLB-7 deposited under ATCC Deposit Accession No. PTA-126841, CJLB-10 deposited under ATCC Deposit Accession No. PTA-126842, CJLB-12 deposited under ATCC Deposit Accession No. PTA-126843, CJLB-13 deposited under ATCC Deposit Accession PTA-126844, CJLB-14 deposited under ATCC Deposit Accession PTA-126845, CJLB-15 deposited under ATCC Deposit Accession PTA-126846, or a combination thereof, or variants of said bacteriophage which have average nucleotide identity over genome of ≥99.9% relative to said bacteriophage, said variants having lytic activity against Campylobacter species or strains, wherein the dietary supplement and/or nutraceutical composition is formulated as a lyophilized or spray-dried powder, an enteric capsule, or a syrup, wherein the bacteriophage in the syrup is stabilized with an effective amount of an agent selected from the group consisting of: a water-soluble polymer or sugar, a derivative of cellulose, a low or medium molecular weight polyvinylpyrrolidone, a glycol with a molecular weight of 4000 or 6000, sodium alginate, a protein, a lipid, a polysaccharide, and a mixture thereof.