US 12,094,594 B2
Method of estimation physiological parameters using medical image data
Ralph Theodorus Hubertus Maessen, Roermond (NL); Sergei Shulepov, Eindhoven (NL); and Marco Baragona, Delft (NL)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Appl. No. 16/980,906
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Mar. 6, 2019, PCT No. PCT/EP2019/055469
§ 371(c)(1), (2) Date Sep. 15, 2020,
PCT Pub. No. WO2019/174973, PCT Pub. Date Sep. 19, 2019.
Claims priority of provisional application 62/746,633, filed on Oct. 17, 2018.
Claims priority of provisional application 62/643,218, filed on Mar. 15, 2018.
Prior Publication US 2021/0012887 A1, Jan. 14, 2021
Int. Cl. G16H 50/50 (2018.01); A61B 5/024 (2006.01); A61B 5/026 (2006.01); A61B 5/03 (2006.01); G06F 30/20 (2020.01); G06F 30/28 (2020.01); G06T 17/20 (2006.01); G16H 30/40 (2018.01); G16H 50/20 (2018.01)
CPC G16H 30/40 (2018.01) [G06F 30/28 (2020.01); G06T 17/205 (2013.01); G16H 50/20 (2018.01)] 16 Claims
OG exemplary drawing
 
1. A method of estimating one or more physiological parameters based on medical imaging data, the method comprising:
receiving an input time-series of three-dimensional medical images representative of a cardiac region of a patient;
applying a meshless simulation framework to simulate blood flow through at least a portion of the imaged cardiac region, wherein the simulation framework comprises simulating force interactions between elements of a simulated fluid, representing blood, and patches of a tissue structure of the cardiac region represented by the time series of images; and
determining one or more physiological parameters based on the simulated blood flow;
wherein the meshless simulation framework comprises at least one of:
i) applying an interaction potential force between the elements of the simulated fluid, and the patches of the tissue structure of the cardiac region, wherein the applied interaction potential force, F, has the form

OG Complex Work Unit Math
where C1 and C2 are pre-determined constants, R is a distance between the elements of the simulated fluid and the patches of an anatomical model of the tissue structure, and a, b are predetermined constants;
ii) modeling an aortic pressure of the imaged cardiac region based on applying a fluid interface within the cardiac region and applying a repulsive potential force between the interface and elements of the modeled fluid; or
iii) applying a pressure correction procedure, which comprises adding a pressure correction term to a pressure parameter assigned to each element of the fluid, the pressure correction term comprising a Taylor expansion of a Poisson equation for pressure; and
wherein the one or more physiological parameter measurements include at least one of: a pressure change from a first point in a fluid path of the cardiac region to a second point in the fluid path, a pressure change between two points along a cardiac valve, cardiac output, a flow speed of blood through a cardiac valve, and a residence time for blood in a ventricle of the heart.