	US 12,092,640 B2
	Methods and compositions for diagnosis of rickettsia infection
Allan R. Brasier, Galveston, TX (US); Yingxin Zhao, Galveston, TX (US); David H. Walker, Galveston, TX (US); and Rong Fang, Galveston, TX (US)
Filed by THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed on Aug. 27, 2020, as Appl. No. 17/004,309.
Claims priority of provisional application 62/892,048, filed on Aug. 27, 2019.
Prior Publication US 2021/0063394 A1, Mar. 4, 2021
Int. Cl. G01N 33/53 (2006.01); G01N 33/563 (2006.01); G01N 33/569 (2006.01)

CPC G01N 33/56911 (2013.01) [G01N 33/563 (2013.01)]

6 Claims

1. A method for detecting acute phase Rickettsial protein RC0497 in a sample comprising:

contacting the sample with antibodies that bind Rickettsial protein RC0497 (SEQ ID NO:1) or Rickettsial protein RC0497 peptides forming an antibody complex with RC0497 peptides in the sample or RC0497 reactive antibodies in the sample, respectively;

isolating the antibody complex; and

identifying the peptides present in the antibody complex.