US 12,092,630 B2
Spatial separation of particles in a particle containing solution for biomedical sensing and detection
Hansong Zeng, Acton, MA (US); and Gert Blankenstein, Concord, MA (US)
Assigned to Instrumentation Laboratory Company, Bedford, MA (US)
Filed by Instrumentation Laboratory Company, Bedford, MA (US)
Filed on Dec. 23, 2021, as Appl. No. 17/560,828.
Application 17/560,828 is a continuation of application No. 14/992,284, filed on Jan. 11, 2016.
Claims priority of provisional application 62/102,308, filed on Jan. 12, 2015.
Prior Publication US 2022/0113293 A1, Apr. 14, 2022
Int. Cl. G01N 33/49 (2006.01); B01L 3/00 (2006.01); G01N 1/40 (2006.01); G01N 33/50 (2006.01)
CPC G01N 33/49 (2013.01) [B01L 3/502715 (2013.01); B01L 3/502761 (2013.01); G01N 1/4077 (2013.01); G01N 33/491 (2013.01); B01L 2200/0647 (2013.01); B01L 2300/06 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/0864 (2013.01); B01L 2400/0436 (2013.01); B01L 2400/0439 (2013.01); G01N 33/5002 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A system comprising:
a channel comprising an inlet configured to receive, from a supply, an amount of blood comprising red blood cells and plasma to fill the channel, the blood forming a column in the channel;
an acoustic transducer positioned relative to the channel to generate acoustic waves that apply acoustic force to the column of blood in the channel to form, in the channel, layers comprising a first layer and second layers, the first layer comprising the plasma, the first layer being substantially free of the red blood cells, and the second layers comprising the red blood cells;
wherein the acoustic transducer is a single acoustic transducer that is external to the channel and that is positioned relative to the channel to generate the acoustic waves to form the first layer in a center of the channel; and
wherein the channel is configured to enable detection, including in a center of the channel, by an optical detector, the optical detector to detect information from which an attribute of the blood can be determined.