US 12,092,606 B2
Compositions and kits comprising interpenetrating polymer network for capillary electrophoresis
Aldrich N. K. Lau, Palo Alto, CA (US); and Jingshe Song, Union City, CA (US)
Assigned to Hongene Biotech Corporation, Union City, CA (US)
Appl. No. 18/039,691
Filed by Hongene Biotech Corporation, Union City, CA (US)
PCT Filed Dec. 14, 2021, PCT No. PCT/US2021/072913
§ 371(c)(1), (2) Date May 31, 2023,
PCT Pub. No. WO2022/133439, PCT Pub. Date Jun. 23, 2022.
Claims priority of provisional application 63/126,941, filed on Dec. 17, 2020.
Prior Publication US 2024/0118238 A1, Apr. 11, 2024
Int. Cl. G01N 27/447 (2006.01); C08L 33/26 (2006.01)
CPC G01N 27/44747 (2013.01) [C08L 33/26 (2013.01)] 27 Claims
 
1. A composition for separating analytes by capillary electrophoresis, comprising:
a sieving component comprising a first non-crosslinked hydrophilic acrylamide polymer; and
a surface interactive component comprising an interpenetrating polymer network (IPN), the IPN comprising at least one non-crosslinked hydrophilic N-vinyl amide polymer and a second non-crosslinked hydrophilic acrylamide polymer;
wherein the composition does not include any crosslinked polymer;
wherein the non-crosslinked hydrophilic N-vinyl amide polymer comprises a recurring unit having the structure of Formula (I):

OG Complex Work Unit Chemistry
wherein
R1 is H or methyl;
R2 is H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted phenyl, or —CH2C(═O)NR4R5;
R3 is methyl; and
each of R4 and R5 is independently H, unsubstituted C1-C6 alkyl, or R4 and R5 together with the nitrogen atom to which they are attached form an optionally substituted 5 or 6 membered heterocyclyl.