US 12,091,462 B2
Antibodies binding to vista at acidic pH
Robert J. Johnston, San Mateo, CA (US); Arvind Rajpal, San Francisco, CA (US); Paul O. Sheppard, Granite Falls, WA (US); Luis Borges, Houston, TX (US); Andrew Rankin, Redwood City, CA (US); Keith Sadoon Bahjat, Woodside, CA (US); Alan J. Korman, Piedmont, CA (US); Xiaodi Deng, San Mateo, CA (US); Lin Hui Su, Somerville, MA (US); Ginger Rakestraw, Somerville, MA (US); Jason R. Pinckney, Westborough, MA (US); David A. Critton, Pennington, NJ (US); Guodong Chen, East Brunswick, NJ (US); Richard Y. Huang, Bridgewater, NJ (US); Ekaterina G. Deyanova, Lawrenceville, NJ (US); Michael Quigley, San Carlos, CA (US); Hadia Lemar, Tracy, CA (US); and Akbar Nayeem, Newtown, PA (US)
Assigned to Five Prime Therapeutics, Inc., Thousand Oaks, CA (US); and Bristol-Myers Squibb Company, Princeton, NJ (US)
Appl. No. 17/258,866
Filed by Five Prime Therapeutics, Inc., South San Francisco, CA (US); and Bristol-Myers Squibb Company, Princeton, NJ (US)
PCT Filed Jul. 10, 2019, PCT No. PCT/US2019/041154
§ 371(c)(1), (2) Date Jan. 8, 2021,
PCT Pub. No. WO2020/014327, PCT Pub. Date Jan. 16, 2020.
Claims priority of provisional application 62/696,622, filed on Jul. 11, 2018.
Claims priority of provisional application 62/733,450, filed on Sep. 19, 2018.
Claims priority of provisional application 62/826,330, filed on Mar. 29, 2019.
Prior Publication US 2022/0073617 A1, Mar. 10, 2022
Int. Cl. C07K 16/00 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/2827 (2013.01) [A61P 35/00 (2018.01); A61K 2039/507 (2013.01); C07K 2317/34 (2013.01); C07K 2317/74 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 20 Claims
 
1. An isolated antibody that binds specifically to human VISTA (hVISTA), wherein the antibody comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH and VL comprise the complementarity determining regions (CDRs) of P1-070976 (SEQ ID Nos: 509-511 and 500-502, respectively), P1-070976_H95D (SEQ ID Nos: 512-514 and 500-502, respectively), VISTA.4 (SEQ ID Nos: 503-505 and 500-502, respectively), P1-065333 (SEQ ID Nos: 506-508 and 500-502, respectively), or P1-070976_E97P (SEQ ID Nos: 515-517 and 500-502, respectively).