US 12,090,459 B2
Photodegradable hydrogel
Kazuaki Matsumura, Ishikawa (JP); and Punnida Nonsuwan, Ishikawa (JP)
Assigned to JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, Ishikawa (JP)
Appl. No. 17/261,421
Filed by JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, Ishikawa (JP)
PCT Filed Jul. 19, 2019, PCT No. PCT/JP2019/028531
§ 371(c)(1), (2) Date Jan. 19, 2021,
PCT Pub. No. WO2020/017651, PCT Pub. Date Jan. 23, 2020.
Claims priority of application No. 2018-137087 (JP), filed on Jul. 20, 2018.
Prior Publication US 2021/0322944 A1, Oct. 21, 2021
Int. Cl. B01J 13/00 (2006.01); A61K 31/7048 (2006.01); A61K 41/00 (2020.01); C08J 3/21 (2006.01); C08J 3/24 (2006.01); A61K 9/06 (2006.01)
CPC B01J 13/0065 (2013.01) [A61K 31/7048 (2013.01); A61K 41/0042 (2013.01); C08J 3/212 (2013.01); C08J 3/24 (2013.01); A61K 9/06 (2013.01); C08J 2305/00 (2013.01); C08J 2479/02 (2013.01)] 10 Claims
 
1. An additive for photodegradable hydrogels, the additive comprising aminated carrageenan gel beads with embedded polydopamine particles.
 
3. A hydrogel having a modified α-glucan crosslinked by dithiothreitol, the modified α-glucan comprising:
at least one group represented by the following formula II:

OG Complex Work Unit Chemistry
in which the R1 group is a C1-C3 alkyl group,
the at least one group represented by the formula II being introduced into α-glucan having a weight average molecular weight in a range of from 2,000 to 200,000 at a degree of substitution in a range of from 10 to 50% per glucose unit of the α-glucan, wherein H of an OH group in the α-glucan is substituted with the group represented by the formula II; and
at least one aldehyde group resulting from oxidation of periodic acid, the at least one aldehyde group being introduced at a degree of substitution in a range of from 25 to 75% per glucose unit of the α-glucan,
wherein aminated carrageenan gel beads with embedded polydopamine particles are embedded in the hydrogel.