US 12,090,338 B2
Immune dose computation for treatment plan optimization in radiotherapy
Jian-Yue Jin, Indianapolis, IN (US); Feng-Ming Kong, Indianapolis, IN (US); Hong Zhang, Wilmington, DE (US); and Huan Yao, Indianapolis, IN (US)
Assigned to Indiana University Research and Technology Corp., Bloomington, IN (US)
Filed by The Trustees of Indiana University, Bloomington, IN (US)
Filed on Jun. 16, 2022, as Appl. No. 17/842,027.
Application 17/842,027 is a continuation of application No. 16/968,849, granted, now 11,389,668, previously published as PCT/US2018/030609, filed on May 2, 2018.
Claims priority of provisional application 62/630,015, filed on Feb. 13, 2018.
Prior Publication US 2023/0021426 A1, Jan. 26, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 5/10 (2006.01)
CPC A61N 5/1031 (2013.01) 20 Claims
OG exemplary drawing
 
1. A radiotherapy system comprising a radiotherapy device configured to deliver a radiotherapy to a patient and a treatment controller having one or more processors and a non-transitory, tangible storage medium containing instructions that, when executed, cause the one or more processors to:
calculate from an initial radiotherapy treatment plan for a patient, an equivalent uniform dose (EUD) for each organ in a target irradiation area in the patient;
calculate an effective dose of radiation to circulating immune cells in blood (EDIC) for the patient by summing all EUDs for all organs in the target irradiation area; and
generate a new patient-specific radiotherapy treatment plan for the patient, wherein the new patient-specific radiotherapy treatment plan decreases a calculated EDIC relative to the initial radiotherapy treatment plan,
wherein the radiotherapy device is configured to deliver radiotherapy to the patient according to the new patient-specific radiotherapy treatment plan;
wherein the new patient-specific radiotherapy treatment plan further maximizes a radiation dose to a tumor; and
wherein the new patient-specific radiotherapy treatment plan results in a calculated EDIC of 6.0 Gy or less.