US 12,090,294 B2
Targeted drug delivery methods using a microneedle
Jae Hwan Jung, Atlanta, GA (US); and Mark R. Prausnitz, Atlanta, GA (US)
Assigned to GEORGIA TECH RESEARCH CORPORATION, Atlanta, GA (US)
Appl. No. 16/609,583
Filed by Georgia Tech Research Corporation, Atlanta, GA (US)
PCT Filed May 2, 2018, PCT No. PCT/US2018/030688
§ 371(c)(1), (2) Date Oct. 30, 2019,
PCT Pub. No. WO2018/204515, PCT Pub. Date Nov. 8, 2018.
Claims priority of provisional application 62/500,209, filed on May 2, 2017.
Prior Publication US 2020/0061357 A1, Feb. 27, 2020
Int. Cl. A61P 27/02 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 31/728 (2006.01); A61M 37/00 (2006.01)
CPC A61M 37/0015 (2013.01) [A61K 9/0009 (2013.01); A61K 9/0019 (2013.01); A61K 9/0048 (2013.01); A61K 9/1652 (2013.01); A61K 31/728 (2013.01); A61P 27/02 (2018.01); A61M 2037/0023 (2013.01); A61M 2037/0061 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method for delivery of a drug formulation to a target tissue in the eye of a subject, the method comprising administering to the suprachoroidal space (SCS) of the subject a first formulation and a second formulation, wherein the first formulation comprises an active agent useful in the treatment of a disease or disorder and the second formulation is a pushing formulation.