US 12,089,930 B2
Method and apparatus for non-invasive hemoglobin level prediction
Md Kamrul Hasan, Milwaukee, WI (US); Sheikh Iqbal Ahamed, Fox Point, WI (US); and Richard R. Love, Madison, WI (US)
Assigned to Marquette University, Milwaukee, WI (US)
Appl. No. 16/978,129
Filed by Marquette University, Milwaukee, WI (US)
PCT Filed Mar. 5, 2019, PCT No. PCT/US2019/020675
§ 371(c)(1), (2) Date Sep. 3, 2020,
PCT Pub. No. WO2019/173283, PCT Pub. Date Sep. 12, 2019.
Claims priority of provisional application 62/638,630, filed on Mar. 5, 2018.
Prior Publication US 2021/0007648 A1, Jan. 14, 2021
Int. Cl. A61B 5/1455 (2006.01); A61B 5/00 (2006.01)
CPC A61B 5/14552 (2013.01) [A61B 5/6826 (2013.01); A61B 5/6898 (2013.01); A61B 2576/02 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A system for non-invasive analysis of a hemoglobin level, the system comprising the following:
a camera;
a first lighting device comprising a near infrared light of a wavelength responsive to blood hemoglobin and adapted to illuminate a finger of a subject;
a second lighting device comprising a near infrared light of a wavelength responsive to blood plasma and adapted to illuminate a finger of a subject;
at least one processor, wherein the at least one processor is programmed to:
receive a first time series of images of a ventral pad of the finger of a subject while illuminated by the first lighting device from a dorsal side of the finger, the first time series of images acquired by the camera under conditions selected to capture at least one complete detailed Photoplethysmography (PPG) cycle representative of blood hemoglobin; and
receive a second time series of images of the ventral pad of the finger of the subject while illuminated by the second lighting device from a dorsal side of the finer, the second time series of images acquired by the camera under conditions to capture at least one complete detailed PPG cycle representative of plasma;
identify at least one feature in the PPG cycle representative of blood hemoglobin;
identify at least one feature in the PPG cycle representative of blood plasma;
provide the identified feature representative of blood hemoglobin and the feature representative of blood plasma to a predictive model adapted to identify a hemoglobin level as a function of the features.