US 12,089,886 B2
Cryogenic applicator
Diede Hendrik Paul Klever, Muiden (NL); and Hubert Clemens Pellikaan, Utrecht (NL)
Assigned to Dutch Renewable Energy B.V., Muiden (NL)
Appl. No. 17/423,136
Filed by Dutch Renewable Energy B.V., Muiden (NL)
PCT Filed Jan. 15, 2020, PCT No. PCT/EP2020/050881
§ 371(c)(1), (2) Date Jul. 15, 2021,
PCT Pub. No. WO2020/148318, PCT Pub. Date Jul. 23, 2020.
Claims priority of application No. 19152564 (EP), filed on Jan. 18, 2019.
Prior Publication US 2022/0133380 A1, May 5, 2022
Int. Cl. A61K 45/06 (2006.01); A61B 18/02 (2006.01); A61B 18/00 (2006.01)
CPC A61B 18/0218 (2013.01) [A61K 45/06 (2013.01); A61B 2018/00017 (2013.01); A61B 2018/00029 (2013.01); A61B 2018/00065 (2013.01); A61B 2018/0047 (2013.01)] 17 Claims
OG exemplary drawing
 
1. An applicator for applying cryogenic fluid to a treatment area, the applicator comprising:
a reservoir configured to contain the cryogenic fluid comprising a gas phase and a liquid phase;
a nozzle arranged in fluid communication with the reservoir to allow dispensing of cryogen from the reservoir through an open distal end of the nozzle to a treatment area;
an actuatable valve configured to selectively allow a flow of cryogenic fluid from the reservoir through the open distal end of the nozzle;
an actuator configured to selectively actuate the actuatable valve;
a spacer extending distally beyond the distal end of the nozzle, the spacer comprising a skin contacting surface at its distal end;
a porous material is provided at least between the open end of the nozzle and the skin contacting surface of the spacer, wherein the porous material is configured to be brought into contact with the treatment area, and wherein the actuatable valve comprises
a mixing chamber and comprising an inlet and an outlet, wherein the inlet comprises a Venturi tube having an entry cone for receiving gas phase from the reservoir, an exit cone and a constricted section that connects the entry cone with the exit cone, said constricted section or said exit cone comprising a liquid inlet for receiving liquid phase from the reservoir, the liquid inlet having a first cross-sectional opening area and the constricted section having a second cross-sectional opening area that is at least 150% larger than the first cross-sectional area, and wherein the nozzle is connected to the outlet of the mixing chamber.