US 12,416,606 B2
Liquid chromatography analysis system
Shinya Imamura, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Appl. No. 17/924,996
Filed by SHIMADZU CORPORATION, Kyoto (JP)
PCT Filed Jan. 8, 2021, PCT No. PCT/JP2021/000477
§ 371(c)(1), (2) Date Nov. 12, 2022,
PCT Pub. No. WO2021/250919, PCT Pub. Date Dec. 16, 2021.
Claims priority of application No. 2020-100123 (JP), filed on Jun. 9, 2020.
Prior Publication US 2023/0184723 A1, Jun. 15, 2023
Int. Cl. G01N 30/32 (2006.01)
CPC G01N 30/32 (2013.01) [G01N 2030/326 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A liquid chromatography analysis system comprising:
a liquid delivery pump that delivers a mobile phase, the liquid delivery pump operating to set a liquid delivery flow rate of a mobile phase to a set flow rate based on a pre-designed correlation between an operation speed and a liquid delivery flow rate;
an autosampler that injects a sample into a mobile phase downstream of the delivery pump;
a separation column for separating components in a sample downstream of the autosampler;
a detector for detecting the components separated in the separation column downstream of the separation column;
a liquid delivery checker configured to execute a liquid delivery check mode of setting a predetermined flow rate to the liquid delivery pump and operating the liquid delivery pump at a timing different from analysis of a sample in order to check a liquid delivery flow rate of the liquid delivery pump; and
a measuring instrument for measuring an amount of a mobile phase delivered by the liquid delivery pump during the liquid delivery check mode, wherein
the liquid delivery checker is configured to obtain an actual measurement value of a flow rate of a mobile phase when operating the liquid delivery pump by setting the predetermined flow rate to the liquid delivery pump using a measurement value obtained by the measuring instrument in the liquid delivery check mode,
the liquid chromatography analysis system further comprising a collection container for collecting a mobile phase delivered by the liquid delivery pump during the liquid delivery check mode,
the measuring instrument is a weight meter for liquid delivery check that measures weight of a mobile phase collected in the collection container, and
the liquid chromatography analysis system further comprising a weight meter for remaining amount measurement, having a wider measurement range than the weight meter for liquid delivery check, that measures weight of a mobile phase container that stores a mobile phase before being delivered by the liquid delivery pump.