US 12,415,869 B2
Chemically induced protein dimerization systems
Liangcai Gu, Seattle, WA (US); Shoukai Kang, Seattle, WA (US); Luis Gomez-Castillo, Seattle, WA (US); and Huayi Jiang, Seattle, WA (US)
Assigned to University of Washington, Seattle, WA (US)
Appl. No. 17/604,928
Filed by UNIVERSITY OF WASHINGTON, Seattle, WA (US)
PCT Filed Apr. 21, 2020, PCT No. PCT/US2020/029052
§ 371(c)(1), (2) Date Oct. 19, 2021,
PCT Pub. No. WO2020/219407, PCT Pub. Date Oct. 29, 2020.
Claims priority of provisional application 62/837,058, filed on Apr. 22, 2019.
Prior Publication US 2022/0177605 A1, Jun. 9, 2022
Int. Cl. C07K 16/44 (2006.01); G01N 33/68 (2006.01)
CPC C07K 16/44 (2013.01) [G01N 33/6845 (2013.01); G01N 33/6854 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01)] 18 Claims
 
1. A single-chain antibody, comprising a set of complementarity-determining regions (CDRs) selected from the group consisting of a CDR1, CDR2, and CDR3 combination comprising the amino acid sequences:
(a) SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:3;
(b) SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO: 6;
(c) SEQ ID NO:7, SEQ ID NO:8, and SEQ ID NO: 9;
(d) SEQ ID NO:10, SEQ ID NO:11, and SEQ ID NO: 12;
(e) SEQ ID NO:13, SEQ ID NO:14, and SEQ ID NO: 15;
(f) SEQ ID NO:16, SEQ ID NO:17, and SEQ ID NO: 18;
(g) SEQ ID NO:19, SEQ ID NO:20, and SEQ ID NO:21;
(h) SEQ ID NO:22, SEQ ID NO:23, and SEQ ID NO:24;
(i) SEQ ID NO:25, SEQ ID NO:26, and SEQ ID NO:27;
(j) SEQ ID NO:28, SEQ ID NO:29, and SEQ ID NO:30;
(k) SEQ ID NO:31, SEQ ID NO:32, and SEQ ID NO:33
(l) SEQ ID NO:34, SEQ ID NO:35, and SEQ ID NO:36;
(m) SEQ ID NO:37, SEQ ID NO:38, and SEQ ID NO:39;
(n) SEQ ID NO:40, SEQ ID NO:41, and SEQ ID NO:42;
(o) SEQ ID NO:43, SEQ ID NO:44, and SEQ ID NO:45;
(p) SEQ ID NO:46, SEQ ID NO:47, and SEQ ID NO:48;
(q) SEQ ID NO:49, SEQ ID NO:50, and SEQ ID NO:51;
(r) SEQ ID NO:52, SEQ ID NO:53, and SEQ ID NO:54;
(s) SEQ ID NO:55, SEQ ID NO:56, and SEQ ID NO:57;
(t) SEQ ID NO:58, SEQ ID NO:59, and SEQ ID NO: 60;
(u) SEQ ID NO:61, SEQ ID NO:62, and SEQ ID NO: 63;
(v) SEQ ID NO:64, SEQ ID NO:65, and SEQ ID NO:66;
(w) SEQ ID NO:67, SEQ ID NO:68, and SEQ ID NO:69;
(x) SEQ ID NO:70, SEQ ID NO:71, and SEQ ID NO: 72;
(y) SEQ ID NO:73, SEQ ID NO:74, and SEQ ID NO:75;
(z) SEQ ID NO:76, SEQ ID NO:77, and SEQ ID NO:78; or
(aa) SEQ ID NO:79, SEQ ID NO:80, and SEQ ID NO:81.