	US 12,415,867 B2
	Anti-DCLK1 antibodies and chimeric antigen receptors, and compositions and methods of use thereof
Courtney W. Houchen, Edmond, OK (US)
Assigned to The Board of Regents of the University of Oklahoma, Norman, OK (US)
Filed by The Board of Regents of the University of Oklahoma, Norman, OK (US)
Filed on Jan. 30, 2024, as Appl. No. 18/427,038.
Application 18/427,038 is a continuation of application No. 16/769,567, granted, now 12,084,514, previously published as PCT/US2018/063702, filed on Dec. 3, 2018.
Claims priority of provisional application 62/594,464, filed on Dec. 4, 2017.
Prior Publication US 2024/0317893 A1, Sep. 26, 2024
Int. Cl. A61P 35/00 (2006.01); A61K 35/17 (2025.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/40 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); G01N 33/50 (2006.01)

CPC C07K 16/40 (2013.01) [A61K 35/17 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4251 (2025.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C12Y 207/11001 (2013.01); G01N 33/5008 (2013.01); G01N 2800/52 (2013.01)]

18 Claims

1. An anti-Doublecortin-like kinase 1 (DCLK1) antibody or antigen binding fragment thereof comprising:

(i) heavy chain (HC) complementarity-determining regions (CDRs) CDRH1, CDRH2, and CDRH3 from an HC immunoglobulin variable domain sequence selected from the group consisting of SEQ ID NOs: 7, 8, 9, 16, 22, 23, and 24; and

(ii) light chain (LC) complementarity-determining regions (CDRs) CDRL1, CDRL2, and CDRL3 from an LC immunoglobulin variable domain sequence selected from the group consisting of SEQ ID NOs: 12, 13, 14, 26, 27, 28, 29, and 30.