US 12,415,066 B2
Biomimetic stimulator system for neural implant
Wentai Liu, Los Angeles, CA (US); Stanislav Culaclii, Los Angeles, CA (US); Po-Min Wang, Los Angeles, CA (US); and Yi-Kai Lo, Los Angeles, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed on Jul. 19, 2022, as Appl. No. 17/813,377.
Application 17/813,377 is a continuation of application No. PCT/US2021/014829, filed on Jan. 24, 2021.
Claims priority of provisional application 62/965,875, filed on Jan. 25, 2020.
Prior Publication US 2022/0409886 A1, Dec. 29, 2022
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01); A61N 1/372 (2006.01); A61N 1/378 (2006.01)
CPC A61N 1/0551 (2013.01) [A61N 1/36153 (2013.01); A61N 1/36175 (2013.01); A61N 1/37223 (2013.01); A61N 1/37247 (2013.01); A61N 1/3727 (2013.01); A61N 1/3787 (2013.01)] 22 Claims
OG exemplary drawing
 
1. An apparatus for generating biomimetic stimulation from a neural implant, comprising:
(a) a control unit;
(b) a stimulator circuit configured for being implanted to provide concurrent multi-channel neural stimulation output through a plurality of stimulator channels;
(c) wherein said control unit communicates with said stimulator circuit through a wired or wireless interface;
(d) a user interface device configured for collecting user inputs for directing stimulation based on randomized inter-pulse-intervals (IPI) to direct multi-channel neural stimulation, comprising:
(i) receiving user input on average required randomized inter-pulse-intervals (IPI) and generating an array of IPI according to an exponential random distribution of pulse periods about a desired average of IPI following a uniform probability distribution in a given range and generating an array containing a set of stimulation parameters containing information on stimulation current pulses and randomized IPI values;
(ii) transmitting said stimulation parameters to said control unit;
(e) wherein the combination of control unit and stimulator circuit are configured for performing direct control of amplitude and width of stimulation for each individual current pulse and their timing based on said stimulation parameters received from said user interface device for each of multiple stimulation output channels.