	US 12,414,967 B2
	Compositions and methods of treating liver disease
Takanori Takebe, Cincinnati, OH (US); and Rie Ouchi, Cincinnati, OH (US)
Assigned to Children's Hospital Medical Center, Cincinnati, OH (US)
Filed by Children's Hospital Medical Center, Cincinnati, OH (US)
Filed on Apr. 24, 2020, as Appl. No. 16/857,338.
Application 16/857,338 is a continuation of application No. 16/343,157, granted, now 10,668,108, previously published as PCT/US2017/059865, filed on Nov. 3, 2017.
Claims priority of provisional application 62/517,414, filed on Jun. 9, 2017.
Claims priority of provisional application 62/417,371, filed on Nov. 4, 2016.
Prior Publication US 2021/0008123 A1, Jan. 14, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/407 (2015.01); A61K 9/00 (2006.01); A61K 31/575 (2006.01); A61K 45/06 (2006.01); A61P 1/16 (2006.01); C12N 5/071 (2010.01); C12N 5/074 (2010.01); C12N 15/01 (2006.01); G01N 33/50 (2006.01)

CPC A61K 35/407 (2013.01) [A61K 9/0029 (2013.01); A61K 31/575 (2013.01); A61P 1/16 (2018.01); C12N 5/0671 (2013.01); C12N 5/0672 (2013.01); C12N 5/0696 (2013.01); C12N 5/0697 (2013.01); C12N 15/01 (2013.01); G01N 33/5008 (2013.01); A61K 45/06 (2013.01); C12N 2500/36 (2013.01); C12N 2501/119 (2013.01); C12N 2506/45 (2013.01)]

8 Claims

1. A method of treating or reducing the occurrence of a steatohepatitis disorder, including NASH, parenteral nutrition associated liver disease (PNALD), and a genetic form of liver disease, comprising the step of administering a composition comprising obeticholic acid and total parenteral nutrition or peripheral parenteral nutrition to an individual in need thereof, wherein the total parenteral nutrition or peripheral parenteral nutrition comprises a lipid emulsion, and wherein said composition is administered parenterally.