US 12,087,564 B2
Tuned synthetic dendrimer calibrants for mass spectrometry
Scott Grayson, New Orleans, LA (US)
Assigned to The Administrators of the Tulane Educational Fund, New Orleans, LA (US)
Filed by The Administrators of the Tulane Educational Fund, New Orleans, LA (US)
Filed on Dec. 21, 2021, as Appl. No. 17/557,879.
Application 16/457,033 is a division of application No. 14/402,474, granted, now 10,347,476, previously published as PCT/US2013/042110, filed on May 21, 2013.
Application 17/557,879 is a continuation of application No. 16/457,033, filed on Jun. 28, 2019, granted, now 11,217,435.
Claims priority of provisional application 61/649,920, filed on May 21, 2012.
Prior Publication US 2022/0384167 A1, Dec. 1, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. H01J 49/00 (2006.01); C07D 319/06 (2006.01); C07D 493/22 (2006.01)
CPC H01J 49/0009 (2013.01) [C07D 319/06 (2013.01); C07D 493/22 (2013.01); H01J 49/004 (2013.01); Y10T 436/10 (2015.01)] 20 Claims
OG exemplary drawing
 
1. A composition comprising:
a first dendrimer comprising a first core molecule, wherein said first core molecule is selected from the group consisting of: a molecule comprising between 1 and 8 alcohol functionalities, a molecule comprising between 1 and 8 amine functionalities, and a molecule comprising at least one amine functionality and at least one alcohol functionality wherein the combined number of amine and alcohol functionalities of said first core molecule is at least 2 but no greater than 8; and
a second dendrimer comprising a second core molecule, wherein said second core molecule is selected from the group consisting of: a molecule comprising between 1 and 8 alcohol functionalities, a molecule comprising between 1 and 8 amine functionalities, and a molecule comprising at least one amine functionality and at least one alcohol functionality wherein the combined number of amine and alcohol functionalities of said second core molecule is at least 2 but no greater than 8;
wherein said first core molecule has a different number of total alcohol functionalities and amine functionalities than said second core molecule;
wherein the first dendrimer and the second dendrimer each have a mass defect falling within a scarcine valley of an average amino acid; and
wherein the first core molecule and the second core molecule each comprise a mass defect marker selected from the group consisting of phosphorous, iodine, bromine, and combinations thereof.