US 12,085,530 B2
Electromechanical approach for cancer detection
Mohammad Abdolahad, Tehran (IR); and Ali Saeidi, Tehran (IR)
Assigned to NANO HESGARSAZAN SALAMAT ARYA NCUBATION CENTER FOR MEDICAL EQUIPMENT AND DEVICES, Tehran (IR)
Filed by Mohammad Abdolahad, Tehran (IR); and Ali Saeidi, Tehran (IR)
Filed on Sep. 10, 2020, as Appl. No. 17/016,435.
Application 17/016,435 is a continuation in part of application No. 15/238,795, filed on Aug. 17, 2016, granted, now 10,775,336.
Claims priority of provisional application 62/263,616, filed on Dec. 5, 2015.
Prior Publication US 2021/0063341 A1, Mar. 4, 2021
Int. Cl. G01N 27/327 (2006.01); C23C 14/16 (2006.01); G01N 27/02 (2006.01); G01N 27/28 (2006.01); G01N 33/483 (2006.01)
CPC G01N 27/3278 (2013.01) [C23C 14/16 (2013.01); G01N 27/028 (2013.01); G01N 27/283 (2013.01); G01N 33/4833 (2013.01)] 18 Claims
OG exemplary drawing
 
1. An electromechanical system for detecting cancerous state of a single cell, comprising:
an aspirating mechanism configured to:
extract a single cell from a suspension of a plurality of suspended biological cells;
hold the extracted single cell; and
apply a mechanical aspiration to the held single cell by applying a suction force to the held single cell;
an electrical measurement mechanism, the electrical measurement mechanism configured to:
apply a set of electrical signals to the single cell before and after applying the mechanical aspiration;
measure a first set of electrical responses from the held single cell corresponding to the applied set of electrical signals before the mechanical aspiration; and
measure a second set of electrical responses from the mechanically aspirated single cell corresponding to the applied set of electrical signals after the mechanical aspiration; and
a processing mechanism comprising a data processor, the processing mechanism configured to detect cancerous state of the single cell based on a difference between the first set of electrical responses and the second set of electrical responses.