	US 12,085,340 B2
	Recombinant virus, composition comprising the same, and uses thereof
Chi-Huey Wong, Rancho Santa Fe, CA (US); and Chung-Yi Wu, Taichung (TW)
Assigned to Academia Sinica, Taipei (TW)
Filed by Academia Sinica, Taipei (TW)
Filed on Sep. 20, 2022, as Appl. No. 17/933,832.
Application 17/933,832 is a continuation of application No. 16/348,421, granted, now 11,480,391, previously published as PCT/US2017/060510, filed on Nov. 8, 2017.
Claims priority of provisional application 62/418,800, filed on Nov. 8, 2016.
Prior Publication US 2023/0074185 A1, Mar. 9, 2023
Int. Cl. F27D 1/12 (2006.01); A61K 39/12 (2006.01); A61K 49/00 (2006.01); F27B 3/14 (2006.01); F27B 3/24 (2006.01); F27D 11/08 (2006.01); F27D 9/00 (2006.01)

CPC F27D 1/12 (2013.01) [A61K 39/12 (2013.01); A61K 49/00 (2013.01); F27B 3/14 (2013.01); F27B 3/24 (2013.01); F27D 11/08 (2013.01); F27D 2009/0021 (2013.01)]

9 Claims

1. A recombinant Influenza A virus (IAV), comprising:

a mutant neuraminidase (NA), which, as compared with its wild-type counterpart, consists of the amino acid sequence of SEQ ID NO: 11, 12 or 13; wherein the mutant NA is defective in neuraminidase activity.