US 12,084,643 B2
Apparatus for measuring electrophysiological signal of three-dimensional cell and method of fabricating the same
Hyunjoo Lee, Daejeon (KR); Chaeyun Shim, Daejeon (KR); Yehhyun Jo, Daejeon (KR); Kiup Kim, Daejeon (KR); Joo-Hyeon Lee, Daejeon (KR); and Eunyoung Jang, Daejeon (KR)
Assigned to KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, Daejeon (KR)
Filed by KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, Daejeon (KR)
Filed on Oct. 28, 2020, as Appl. No. 17/082,344.
Claims priority of application No. 10-2020-0079268 (KR), filed on Jun. 29, 2020.
Prior Publication US 2021/0403845 A1, Dec. 30, 2021
Int. Cl. C12M 1/00 (2006.01); B01L 3/00 (2006.01); B01L 99/00 (2010.01); C12M 1/32 (2006.01); C12M 1/34 (2006.01); G01N 15/1031 (2024.01); G01N 15/12 (2024.01)
CPC C12M 23/26 (2013.01) [B01L 3/505 (2013.01); C12M 23/12 (2013.01); C12M 41/00 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0609 (2013.01); B01L 2300/0848 (2013.01); B01L 2300/123 (2013.01)] 5 Claims
OG exemplary drawing
 
1. An apparatus for measuring an electrophysiological signal of at least one cell, the apparatus comprising:
a flexible substrate comprising a plurality of protrusions and a cantilever structure in which the plurality of protrusions are centered; and
a conductor formed on the plurality of protrusions,
wherein regions other than the plurality of protrusions are partially removed from the flexible substrate,
wherein the flexible substrate has a serpentine structure in which the plurality of protrusions are connected to each other via serpentine lines.