US 12,084,490 B2
Antibody based reagents that specifically recognize toxic oligomeric forms of tau
Michael Sierks, Ft. McDowell, AZ (US); and Huilai Tian, Tempe, AZ (US)
Assigned to ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US)
Filed by ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US)
Filed on May 21, 2021, as Appl. No. 17/327,462.
Application 17/327,462 is a continuation of application No. 16/672,034, filed on Nov. 1, 2019, granted, now 11,046,755.
Application 16/672,034 is a continuation of application No. 16/365,469, filed on Mar. 26, 2019, abandoned.
Application 16/365,469 is a continuation of application No. 15/881,392, filed on Jan. 26, 2018, abandoned.
Application 15/881,392 is a continuation of application No. 15/479,110, filed on Apr. 4, 2017, granted, now 9,915,668, issued on Mar. 13, 2018.
Application 15/479,110 is a continuation of application No. 14/434,742, granted, now 9,650,436, issued on Sep. 24, 2015, previously published as PCT/US2013/065104, filed on Oct. 15, 2013.
Claims priority of provisional application 61/713,441, filed on Oct. 12, 2012.
Prior Publication US 2021/0324060 A1, Oct. 21, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/18 (2006.01); A61K 39/00 (2006.01); C07K 16/00 (2006.01); C12N 15/10 (2006.01); G01N 33/68 (2006.01)
CPC C07K 16/18 (2013.01) [C07K 16/005 (2013.01); C12N 15/1037 (2013.01); G01N 33/6896 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/30 (2013.01); C07K 2317/62 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); G01N 2333/47 (2013.01); G01N 2333/4703 (2013.01); G01N 2800/28 (2013.01); G01N 2800/2814 (2013.01); G01N 2800/2821 (2013.01); G01N 2800/7047 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A binding molecule comprising six complementarity determining regions (CDRs) having amino acid sequences SYAMS (SEQ ID NO: 57), AISGSGGSTYYADSVKG (SEQ ID NO: 58), GGDYGSGDY (SEQ ID NO: 59), QGDSLRSYYAS (SEQ ID NO: 60), GKNIRPS (SEQ ID NO: 61), and HSRDSSGTHLRV (SEQ ID NO: 62) wherein the binding molecule has 80% sequence identity to SEQ ID NO: 11.