US 12,084,473 B2
β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
Jean-Pierre Sommadossi, Boston, MA (US); and Adel Moussa, Burlington, MA (US)
Assigned to Atea Pharmaceuticals, Inc., Boston, MA (US)
Filed by Atea Pharmaceuticals, Inc., Boston, MA (US)
Filed on Jan. 23, 2023, as Appl. No. 18/100,452.
Application 18/100,452 is a continuation of application No. 17/306,643, filed on May 3, 2021, abandoned.
Application 17/306,643 is a continuation of application No. 17/028,724, filed on Sep. 22, 2020, abandoned.
Application 17/028,724 is a continuation of application No. 16/918,914, filed on Jul. 1, 2020, granted, now 10,875,885, issued on Dec. 29, 2020.
Application 16/918,914 is a continuation of application No. 16/900,397, filed on Jun. 12, 2020, granted, now 10,870,672, issued on Dec. 22, 2020.
Application 16/900,397 is a continuation of application No. 16/278,621, filed on Feb. 18, 2019, granted, now 10,815,266, issued on Oct. 27, 2020.
Application 16/278,621 is a continuation of application No. 16/001,549, filed on Jun. 6, 2018, granted, now 10,239,911, issued on Mar. 26, 2019.
Application 16/001,549 is a continuation of application No. 15/782,628, filed on Oct. 12, 2017, granted, now 10,000,523, issued on Jun. 19, 2018.
Application 15/782,628 is a continuation of application No. 15/063,461, filed on Mar. 7, 2016, granted, now 9,828,410, issued on Nov. 28, 2017.
Claims priority of provisional application 62/276,597, filed on Jan. 8, 2016.
Claims priority of provisional application 62/253,958, filed on Nov. 11, 2015.
Claims priority of provisional application 62/129,319, filed on Mar. 6, 2015.
Prior Publication US 2024/0002426 A1, Jan. 4, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07H 19/207 (2006.01); A61K 31/7076 (2006.01); A61P 31/14 (2006.01); C07H 19/16 (2006.01); C07H 19/20 (2006.01)
CPC C07H 19/207 (2013.01) [A61K 31/7076 (2013.01); A61P 31/14 (2018.01); C07H 19/16 (2013.01); C07H 19/20 (2013.01)] 29 Claims
 
1. A compound of Formula:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein:
Y is NR1R2;
R1 is methyl;
R2 is hydrogen;
R3 is hydrogen; and
R4 is a thiophosphoramidate.