US 12,084,455 B2
HIV inhibitor compounds
Elizabeth M. Bacon, Burlingame, CA (US); Elbert Chin, San Mateo, CA (US); Jeromy J. Cottell, Redwood City, CA (US); Ashley Anne Katana, North Olmstead, OH (US); Darryl Kato, San Francisco, CA (US); John O. Link, San Francisco, CA (US); Nathan Shapiro, Belmont, CA (US); Teresa Alejandra Trejo Martin, Belmont, CA (US); and Zheng-Yu Yang, Palo Alto, CA (US)
Assigned to Gilead Sciences, Inc., Foster City, CA (US)
Filed by Gilead Sciences, Inc., Foster City, CA (US)
Filed on Apr. 7, 2021, as Appl. No. 17/224,557.
Application 17/224,557 is a continuation of application No. 16/805,933, filed on Mar. 2, 2020, granted, now 11,078,208.
Application 16/805,933 is a continuation of application No. 16/364,487, filed on Mar. 26, 2019, granted, now 10,752,636, issued on Aug. 25, 2020.
Application 16/364,487 is a continuation of application No. 15/888,749, filed on Feb. 5, 2018, granted, now 10,294,234, issued on May 21, 2019.
Claims priority of provisional application 62/455,348, filed on Feb. 6, 2017.
Prior Publication US 2023/0027055 A1, Jan. 26, 2023
Int. Cl. C07D 405/14 (2006.01); A61K 31/52 (2006.01); A61K 31/55 (2006.01); A61K 31/553 (2006.01); A61K 31/685 (2006.01); A61K 31/688 (2006.01); A61K 45/06 (2006.01); A61P 31/18 (2006.01); C07C 243/28 (2006.01); C07C 275/16 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 471/08 (2006.01); C07D 487/08 (2006.01); C07D 487/10 (2006.01); C07D 491/04 (2006.01)
CPC C07D 487/08 (2013.01) [A61K 31/52 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); A61K 31/685 (2013.01); A61K 31/688 (2013.01); A61K 45/06 (2013.01); A61P 31/18 (2018.01); C07C 243/28 (2013.01); C07C 275/16 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01); C07D 471/08 (2013.01); C07D 487/10 (2013.01); C07D 491/04 (2013.01)] 18 Claims
 
1. A process of preparing compound:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, comprising reacting Compound S3:

OG Complex Work Unit Chemistry
with a compound of structure:

OG Complex Work Unit Chemistry