US 12,084,425 B2
Method for preparing escitalopram bis-hydroxynaphtoate crystal form a
Wei Xu, Shanghai (CN); Xi Chen, Shanghai (CN); and Hong Gu, Shanghai (CN)
Assigned to ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, Zhejiang (CN); and SHANGHAI AOBO PHARMTECH, INC., LTD., Shanghai (CN)
Appl. No. 17/295,843
Filed by ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., Zhejiang (CN); and SHANGHAI AOBO PHARMTECH, INC., LTD., Shanghai (CN)
PCT Filed Oct. 12, 2019, PCT No. PCT/CN2019/110807
§ 371(c)(1), (2) Date May 20, 2021,
PCT Pub. No. WO2020/108117, PCT Pub. Date Jun. 4, 2020.
Claims priority of application No. 201811212608.5 (CN), filed on Nov. 26, 2018.
Prior Publication US 2021/0276968 A1, Sep. 9, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 307/87 (2006.01)
CPC C07D 307/87 (2013.01) [C07B 2200/13 (2013.01)] 13 Claims
 
1. A method for preparing a crystal form A of a compound of formula I, comprising:
dissolving escitalopram oxalate in a reaction solvent to obtain an escitalopram oxalate solution;
and adding a solution of a pamoate salt dropwise to precipitate the crystal form A of the compound of formula I

OG Complex Work Unit Chemistry