US 12,084,411 B2
Hinokitiol analogues, methods of preparing and pharmaceutical compositions thereof
Martin D. Burke, Champaign, IL (US); Anthony S. Grillo, Champaign, IL (US); Alexander G. Cioffi, Urbana, IL (US); Anna SantaMaria, Rockville, MD (US); Daniel Blair, Hull (GB); and Andrew Blake, Urbana, IL (US)
Assigned to The Board of Trustees of the University of Illinois, Urbana, IL (US)
Appl. No. 17/046,608
Filed by The Board of Trustees of the University of Illinois, Urbana, IL (US)
PCT Filed Apr. 12, 2019, PCT No. PCT/US2019/027314
§ 371(c)(1), (2) Date Oct. 9, 2020,
PCT Pub. No. WO2019/200314, PCT Pub. Date Oct. 17, 2019.
Claims priority of provisional application 62/657,127, filed on Apr. 13, 2018.
Prior Publication US 2021/0163393 A1, Jun. 3, 2021
Int. Cl. C07C 45/68 (2006.01); A61K 45/06 (2006.01); C07C 61/22 (2006.01)
CPC C07C 45/68 (2013.01) [A61K 45/06 (2013.01); C07C 61/22 (2013.01)] 25 Claims
 
1. A compound having a structure according to Formula (I):

OG Complex Work Unit Chemistry
or a salt thereof; wherein
Ra is selected from the group consisting of

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
Rb is hydrogen or methyl;
provided that if Ra is

OG Complex Work Unit Chemistry
then Rb is methyl.