US 12,083,356 B2
Model based PBS optimization for flash therapy treatment planning and oncology information system
Michael Matthew Folkerts, Carrollton, TX (US); Jessica Perez, Geneva (CH); Christel Smith, Santa Barbara, CA (US); Eric Abel, San Jose, CA (US); Anthony Magliari, Newark, IL (US); Reynald Vanderstraeten, Uccle (BE); Timo Kalevi Koponen, Espoo (FI); Renate Parry, Oakland, CA (US); Alexander Katsis, San Mateo, CA (US); Rajiv Dua, Manteca, CA (US); Michiko Alcanzare, Espoo (FI); Perttu Niemela, Espoo (FI); and Matti Ropo, Turku (FI)
Assigned to SIEMENS HEALTHINEERS INTERNATIONAL AG, Steinhausen (CH); VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH & CO. KG, Troisdorf (DE); and VARIAN MEDICAL SYSTEMS INC, Palo Alto, CA (US)
Filed by Varian Medical Systems, Inc., Palo Alto, CA (US); Varian Medical Systems International AG, Steinhausen (CH); and Varian Medical Systems Particle Therapy GmbH & Co. KG, Troisdorf (DE)
Filed on Jul. 22, 2021, as Appl. No. 17/383,345.
Application 17/383,345 is a continuation of application No. 16/438,174, filed on Jun. 11, 2019, granted, now 11,103,727.
Application 16/438,174 is a continuation in part of application No. 16/297,448, filed on Mar. 8, 2019, granted, now 11,090,508.
Prior Publication US 2021/0346719 A1, Nov. 11, 2021
Int. Cl. A61N 5/10 (2006.01); G06T 7/00 (2017.01)
CPC A61N 5/1031 (2013.01) [G06T 7/0012 (2013.01); A61N 2005/1032 (2013.01); G06T 2207/10076 (2013.01); G06T 2207/30004 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A computer-implemented method comprising:
receiving an input parameter for each voxel of a plurality of voxels of a treatment map, wherein the input parameter is included in a radiotherapy treatment plan;
generating a biological outcome map that assigns a respective value to said each voxel of the treatment map, wherein the respective value for said each voxel is based on a model that relates a value of the input parameter for said each voxel to a biological outcome for said each voxel; and
modifying the radiotherapy treatment plan based on the respective value for said each voxel comprised in the biological outcome map, wherein said modifying comprises adjusting the value of the input parameter to modify the respective value for said each voxel;
wherein said modifying further comprises implementing quantitative time-dependent model-based charged particle pencil beam scanning optimization for FLASH therapy.