US 12,083,342 B2
Neuromodulation device
Alessandra Giarola, Stevenage (GB); Yee-Hsee Hsieh, Cleveland, OH (US); Stephen J. Lewis, Cleveland, OH (US); and Arun Sridhar, Stevenage (GB)
Assigned to Galvani Bioelectronics Limited, (GB); and Case Western Reserve University, Cleveland, OH (US)
Filed by Galvani Bioelectronics Limited, Middlesex (GB); and Case Western Reserve University, Cleveland, OH (US)
Filed on Aug. 8, 2022, as Appl. No. 17/883,332.
Application 17/883,332 is a continuation of application No. 16/080,203, granted, now 11,452,872, previously published as PCT/IB2017/051143, filed on Feb. 27, 2017.
Claims priority of provisional application 62/301,198, filed on Feb. 29, 2016.
Prior Publication US 2023/0017399 A1, Jan. 19, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61B 5/00 (2006.01); A61B 5/08 (2006.01); A61N 1/00 (2006.01); A61N 1/05 (2006.01); A61N 1/18 (2006.01)
CPC A61N 1/3611 (2013.01) [A61B 5/0826 (2013.01); A61B 5/4818 (2013.01); A61N 1/00 (2013.01); A61N 1/0556 (2013.01); A61N 1/18 (2013.01); A61N 1/36 (2013.01)] 17 Claims
OG exemplary drawing
 
1. An apparatus for treating sleep apnea in a subject, the apparatus comprising:
i. at least two implantable neural interfacing elements each having one or more electrodes, wherein one of the at least two implantable neural interfacing elements is configured to be in signaling contact with at least one of a left cervical sympathetic chain (CSC), a left superior cervical ganglion (SCG) or postganglionic branch thereof to induce a change in a first parameter associated with sleep apnea and wherein the other one of the at least two implantable neural interfacing elements is configured to be in signaling contact with at least one of a right cervical sympathetic chain (CSC), a right superior cervical ganglion (SCG) or postganglionic branch thereof to induce change in a second parameter associated with sleep apnea; and
ii. a controller operably coupled to the at least two implantable neural interfacing elements, the controller causes the at least two implantable neural interfacing elements to deliver electrical signals that increase localized sympathetic activity of the left CSC, left SCG or postganglionic branch thereof and the right CSC, the right SCG or postganglionic branch thereof,
wherein the increased sympathetic activity of at least one of the CSC, SCG or postganglionic branch ameliorates sleep apnea in the subject, and further wherein the electrical signals induce changes to the first parameter and the second parameter and modulate different aspects of sleep apnea.