US 12,083,285 B2
Aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal CPAP device
Andrew R. Clark, San Mateo, CA (US); and James B. Fink, San Mateo, CA (US)
Assigned to Stamford Devices Ltd., Dangan (IE)
Filed by Stamford Devices Ltd., Galway (IE)
Filed on May 26, 2020, as Appl. No. 16/883,677.
Claims priority of provisional application 62/852,867, filed on May 24, 2019.
Claims priority of provisional application 62/852,862, filed on May 24, 2019.
Prior Publication US 2020/0368457 A1, Nov. 26, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 16/14 (2006.01); A61M 11/00 (2006.01); A61M 15/00 (2006.01); A61M 16/04 (2006.01); A61M 16/06 (2006.01); A61M 16/08 (2006.01); A61M 39/10 (2006.01)
CPC A61M 16/14 (2013.01) [A61M 11/001 (2014.02); A61M 15/009 (2013.01); A61M 16/0465 (2013.01); A61M 16/0488 (2013.01); A61M 16/0666 (2013.01); A61M 16/0816 (2013.01); A61M 16/0883 (2014.02); A61M 11/005 (2013.01); A61M 2039/1077 (2013.01); A61M 2202/0488 (2013.01); A61M 2205/0294 (2013.01); A61M 2205/3379 (2013.01); A61M 2205/581 (2013.01); A61M 2205/583 (2013.01); A61M 2205/8206 (2013.01); A61M 2230/40 (2013.01); A61M 2240/00 (2013.01)] 39 Claims
OG exemplary drawing
 
1. An aerosolization system, comprising:
a respiration system comprising an inspiratory limb and an expiratory limb;
an aerosolization device, comprising:
an aerosol chamber having a first end and a second end;
an aerosol generator positioned at the first end of the aerosol chamber, the aerosol generator comprises a vibratable mesh, wherein:
the aerosol generator comprises a reservoir that is configured to receive a volume of liquid medicament for aerosolization by the aerosol generator; and
the vibratable mesh of the aerosol generator is configured to aerosolize the volume of medicament into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 μm at a rate of at least 0.1 ml/min;
a patient interface that is positioned proximate the second end of the aerosol chamber; and
a respiratory adaptor that is configured to couple the aerosolization device with the respiration system, wherein:
the respiratory adaptor comprises a diversion mechanism that is configured to divert a portion of airflow from the respiration system into the aerosol chamber via at least one airway;
the at least one airway introduces the portion of airflow into the aerosol chamber proximate the first end and the aerosol generator; and
the aerosol chamber is configured to mix the portion of airflow with aerosolized medicament from the aerosol generator;
at least one breath sensor that is configured to detect an inhalation of a patient; and
a controller that is configured to actuate the aerosol generator to aerosolize the volume of medicament in synchronization with the detected inhalation.