	US 12,083,220 B1
	Combination treatment for antibiotic resistant infections
Hany Mohamed Abd El-Lateef Ahmed, Al-Ahsa (SA); Mai Mostafa Khalaf Ali, Al-Ahsa (SA); Mohamed Ahmed El-Mokhtar, Al-Ahsa (SA); Mohammed Sherif Saddik Ibrahim, Al-Ahsa (SA); and Ahmed Mohammed Abu-Dief Mohammed, Al-Ahsa (SA)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on Nov. 17, 2023, as Appl. No. 18/512,722.
Application 18/512,722 is a division of application No. 18/192,432, filed on Mar. 29, 2023.
Int. Cl. A61K 9/06 (2006.01); A61K 31/5377 (2006.01); A61K 31/546 (2006.01); A61K 47/38 (2006.01); A61K 47/69 (2017.01); A61P 17/02 (2006.01); A61P 31/04 (2006.01); B82Y 5/00 (2011.01)

CPC A61K 9/06 (2013.01) [A61K 31/5377 (2013.01); A61K 31/546 (2013.01); A61K 47/38 (2013.01); A61K 47/6903 (2017.08); A61P 17/02 (2018.01); A61P 31/04 (2018.01); B82Y 5/00 (2013.01)]

3 Claims

1. A method of making a composition comprising zinc oxide nanoparticles loaded with linezolid and ceftriaxone, comprising:

(a) mixing an aqueous solution of zinc oxide nanoparticles with an aqueous solution comprising equal weights of ceftriaxone sodium and linezolid to produce a mixture;

(b) incubating and shaking the mixture;

(c) filtering the mixture to obtain the zinc oxide nanoparticles loaded with linezolid and ceftriaxone, wherein the method further comprises:

(a1) heating Echinacea purpurea liquid extract to 80° C.;

(b1) adding zinc nitrate hexahydrate to produce a white precipitate;

(c1) drying and heating the white precipitate to obtain zinc oxide nanoparticles; and

(d1) adding the zinc oxide nanoparticles to a solvent to obtain the aqueous solution of zinc oxide nanoparticles.