US 12,083,185 B2
Small polymeric carriers for delivery of agents
Jingjing Sun, Pittsburgh, PA (US); and Song Li, Mars, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Appl. No. 17/284,562
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
PCT Filed Oct. 11, 2019, PCT No. PCT/US2019/055766
§ 371(c)(1), (2) Date Apr. 12, 2021,
PCT Pub. No. WO2020/077170, PCT Pub. Date Apr. 16, 2020.
Claims priority of provisional application 62/744,928, filed on Oct. 12, 2018.
Prior Publication US 2021/0330808 A1, Oct. 28, 2021
Int. Cl. A61K 47/69 (2017.01); A61K 9/107 (2006.01); A61K 31/12 (2006.01); A61K 31/138 (2006.01); A61K 31/337 (2006.01); A61K 31/366 (2006.01); A61K 31/404 (2006.01); A61K 31/405 (2006.01); A61K 31/436 (2006.01); A61K 31/506 (2006.01); A61K 31/551 (2006.01); A61K 31/7068 (2006.01); A61K 38/13 (2006.01); A61K 47/54 (2017.01); A61K 47/58 (2017.01); A61K 47/60 (2017.01)
CPC A61K 47/6907 (2017.08) [A61K 9/1075 (2013.01); A61K 31/12 (2013.01); A61K 31/138 (2013.01); A61K 31/337 (2013.01); A61K 31/366 (2013.01); A61K 31/404 (2013.01); A61K 31/405 (2013.01); A61K 31/436 (2013.01); A61K 31/506 (2013.01); A61K 31/551 (2013.01); A61K 31/7068 (2013.01); A61K 38/13 (2013.01); A61K 47/54 (2017.08); A61K 47/542 (2017.08); A61K 47/58 (2017.08); A61K 47/60 (2017.08)] 42 Claims
 
1. A polymer, comprising:
(1) an alkylene polymer backbone,
(2) a first plurality of pendant groups attached to the alkylene polymer backbone and comprising a therapeutic or diagnostic agent comprising a plurality of hydroxyl groups, and
(3) a second plurality of pendant groups attached to the alkylene polymer backbone and comprising at least one hydrophilic polymer,
wherein the first plurality of pendant groups is attached to the alkylene polymer backbone via a linking moiety comprising at least one benzyl group which is interactive via π-π stacking.