	US 12,083,160 B2
	Polypeptides binding to human complement C5
Charlotta Berghard, Stockholm (SE); Magnus Berglund, Vendelsö (SE); Patrik Strömberg, Sollentuna (SE); Malin Lindborg, Saltsjö-Boo (SE); Elin Gunneriusson, Saltsjöbaden (SE); and Joachim Feldwisch, Tyresö (SE)
Assigned to IPC Research, LLC, Wilmington, DE (US)
Filed by IPC Research, LLC, Wilmington, DE (US)
Filed on Sep. 20, 2021, as Appl. No. 17/479,101.
Application 17/479,101 is a continuation of application No. 16/228,181, filed on Dec. 20, 2018, granted, now 11,123,401.
Application 16/228,181 is a continuation of application No. 15/721,507, filed on Sep. 29, 2017, granted, now 10,206,975, issued on Feb. 19, 2019.
Application 15/721,507 is a continuation of application No. 14/378,522, granted, now 9,808,502, issued on Nov. 7, 2017, previously published as PCT/SE2013/050139, filed on Feb. 19, 2013.
Claims priority of application No. 1250145-8 (SE), filed on Feb. 20, 2012.
Prior Publication US 2021/0401930 A1, Dec. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/00 (2006.01); A61K 38/16 (2006.01); A61K 47/64 (2017.01); A61K 47/68 (2017.01); C07K 14/195 (2006.01); C07K 14/315 (2006.01); C07K 14/47 (2006.01); C07K 19/00 (2006.01); A61K 38/00 (2006.01)

CPC A61K 38/164 (2013.01) [A61K 38/16 (2013.01); A61K 47/64 (2017.08); A61K 47/68 (2017.08); A61K 47/6801 (2017.08); C07K 14/00 (2013.01); C07K 14/195 (2013.01); C07K 14/315 (2013.01); C07K 14/47 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/31 (2013.01)]

15 Claims

1. A C5 binding polypeptide comprising, from N-terminal to C-terminal:

(a) a three-helix bundle protein domain, wherein the bundle protein domain comprises a C5 binding motif, BM, comprising the amino acid sequence of SEQ ID NO. 1,

(b) a linking moiety, wherein the linking moiety comprises the amino acid sequence GS, and