US 12,083,158 B2
Antibacterial compositions, methods of making and use thereof
Vincent Craig Bond, Stone Mountain, GA (US); Michael Powell, Douglasville, GA (US); Ming Bo Huang, Atlanta, GA (US); Syed Ali, New Iberia, LA (US); and Martin N. Shelton, Seattle, WA (US)
Assigned to Morehouse School of Medicine, Atlanta, GA (US)
Filed by MOREHOUSE SCHOOL OF MEDICINE, Atlanta, GA (US)
Filed on Dec. 19, 2018, as Appl. No. 16/226,242.
Application 16/226,242 is a continuation in part of application No. 15/397,359, filed on Jan. 3, 2017, granted, now 10,206,974.
Application 15/397,359 is a continuation of application No. 14/156,119, filed on Jan. 15, 2014, granted, now 9,556,224, issued on Jan. 31, 2017.
Application 14/156,119 is a continuation of application No. 13/267,977, filed on Oct. 7, 2011, granted, now 8,669,226, issued on Mar. 11, 2014.
Claims priority of provisional application 62/678,002, filed on May 30, 2018.
Prior Publication US 2019/0134151 A1, May 9, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/00 (2006.01); A61K 38/08 (2019.01); A61K 38/16 (2006.01); A61K 45/06 (2006.01); A61K 47/60 (2017.01); A61K 47/64 (2017.01); C07K 7/06 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01)
CPC A61K 38/162 (2013.01) [A61K 38/08 (2013.01); A61K 45/06 (2013.01); A61K 47/60 (2017.08); A61K 47/6455 (2017.08); C07K 7/06 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C07K 2319/10 (2013.01); C12N 2740/16032 (2013.01); C12N 2740/16322 (2013.01); Y02A 50/30 (2018.01)] 5 Claims
 
1. A biologically compatible anti-biofilm coating or impregnator for detaching or dispersing gram-positive or gram-negative bacterial biofilms;
wherein the anti-biofilm coating or impregnator is selected from the group consisting of paint, glue, or cement;
wherein the anti-biofilm paint, glue, or cement comprises a gram-positive or gram-negative anti-bacterial secretion modifying region (SMR) peptide;
wherein the SMR peptide consists of the amino acid sequence of SEQ ID NO: 9;
wherein the anti-biofilm paint, glue, or cement further comprises the SMR peptide SEQ ID NO: 9 in an effective concentration to inhibit biofilm formation by at least greater than 80% by any gram-positive or gram-negative bacteria;
and wherein the anti-biofilm coating or impregnator does not contain a bacterial biofilm-degrading enzyme.