	US 12,083,131 B2
	Neuroactive steroids, compositions, and uses thereof
Stephen Jay Kanes, Brynlawn, PA (US); and Helen Colquhoun, Arlington, MA (US)
Assigned to Sage Therapeutics, Inc., Cambridge, MA (US)
Filed by Sage Therapeutics, Inc., Cambridge, MA (US)
Filed on Feb. 10, 2020, as Appl. No. 16/786,160.
Application 16/786,160 is a division of application No. 15/509,656, abandoned, previously published as PCT/US2015/048937, filed on Sep. 8, 2015.
Claims priority of provisional application 62/213,015, filed on Sep. 1, 2015.
Claims priority of provisional application 62/170,596, filed on Jun. 3, 2015.
Claims priority of provisional application 62/047,599, filed on Sep. 8, 2014.
Prior Publication US 2020/0253985 A1, Aug. 13, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/573 (2006.01); A61K 9/00 (2006.01); A61K 31/57 (2006.01); A61K 47/40 (2006.01)

CPC A61K 31/573 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 31/57 (2013.01); A61K 47/40 (2013.01)]

16 Claims

1. A method of treating postpartum depression in a human subject, the method comprising administering a continuous intravenous infusion of allopregnanolone, wherein the infusion comprises administering a first infusion, second infusion, and third infusion to the subject in need thereof, and wherein the first infusion delivers a smaller amount, as measured in μg/kg/hour, of allopregnanolone/unit time than the second infusion, and wherein the third infusion delivers a smaller amount, as measured in μg/kg/hour, of allopregnanolone/unit time than the second infusion, and wherein

said first infusion comprises administering a continuously increasing amount of allopregnanolone at an amount of allopregnanolone/unit time of 5-100 μg/kg/hour, 10-80 μg/kg/hour, or 15-70 μg/kg/hour;

said second infusion comprises administering an amount of allopregnanolone/unit time of 50-100 μg/kg/hour, 70-100 μg/kg/hour, or 86 μg/kg/hour; and

said third infusion comprises administering a continuously decreasing amount of allopregnanolone at an amount of allopregnanolone/unit time of 5-100 μg/kg/hour, 10-80 μg/kg/hour, or 15-70 μg/kg/hour.