US 12,083,123 B2
Method for the detection of drug-induced organ or tissue injury in IMPDH inhibitor treated patients
Atsuo Sasaki, Cincinnati, OH (US); and Mikako Warren, Pasadena, CA (US)
Filed by University of Cincinnati, Cincinnati, OH (US); and Children's Hospital Los Angeles, Los Angeles, CA (US)
Filed on Oct. 6, 2021, as Appl. No. 17/494,968.
Claims priority of provisional application 63/088,106, filed on Oct. 6, 2020.
Prior Publication US 2022/0105099 A1, Apr. 7, 2022
Int. Cl. A61K 31/5377 (2006.01); A61P 1/16 (2006.01); G01N 33/50 (2006.01)
CPC A61K 31/5377 (2013.01) [A61P 1/16 (2018.01); G01N 33/5008 (2013.01)] 13 Claims
 
1. A method for detecting injury to a tissue in a subject undergoing a drug regimen for tissue or organ transplantation, comprising:
obtaining a tissue or organ sample from a transplanted tissue or organ in a subject at a first time point;
determining the presence of aberrant mitochondria in the tissue or organ sample, wherein the aberrant mitochondria in the tissue or organ sample signify injury to the transplanted tissue or organ; and,
taking remedial action to prevent further injury to the transplanted tissue or organ.