US 12,083,121 B2
Substituted piperazines as KRAS G12C inhibitors
John Gordon Allen, Newbury Park, CA (US); Brian Alan Lanman, Woodland Hills, CA (US); Jian Chen, San Diego, CA (US); Anthony B. Reed, Newbury Park, CA (US); Victor J. Cee, Thousand Oaks, CA (US); Longbin Liu, Thousand Oaks, CA (US); Patricia Lopez, Woodland Hills, CA (US); Ryan Paul Wurz, Newbury Park, CA (US); Thomas T. Nguyen, Newbury Park, CA (US); Shon Booker, Sherman Oaks, CA (US); Jennifer Rebecca Allen, Newbury Park, CA (US); Margaret Chu-Moyer, Brookline, MA (US); Albert Amegadzie, Westlake Village, CA (US); Ning Chen, Thousand Oaks, CA (US); Clifford Goodman, Calabasas, CA (US); Jonathan D. Low, Northridge, CA (US); Vu Van Ma, Oak Park, CA (US); Ana Elena Minatti, Santa Monica, CA (US); Nobuko Nishimura, West Hills, CA (US); Alexander J. Pickrell, Westlake Village, CA (US); Hui-Ling Wang, Thousand Oaks, CA (US); Youngsook Shin, Seoul (KR); Aaron C. Siegmund, Ventura, CA (US); Kevin C. Yang, San Gabriel, CA (US); Nuria A. Tamayo, Newbury Park, CA (US); Mary Walton, Camarillo, CA (US); and Qiufen Xue, Thousand Oaks, CA (US)
Assigned to Amgen Inc., Thousand Oaks, CA (US)
Filed by AMGEN INC., Thousand Oaks, CA (US)
Filed on Jan. 19, 2022, as Appl. No. 17/579,359.
Application 17/579,359 is a division of application No. 16/438,349, filed on Jun. 11, 2019, granted, now 11,285,156.
Claims priority of provisional application 62/684,117, filed on Jun. 12, 2018.
Prior Publication US 2022/0175782 A1, Jun. 9, 2022
Int. Cl. C07D 241/04 (2006.01); A61K 31/519 (2006.01); A61K 31/551 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 31/551 (2013.01); A61K 39/39558 (2013.01); A61P 35/00 (2018.01)] 5 Claims
 
1. A method for inhibiting KRAS G12C activity in a subject in need thereof, wherein the method comprising administering to the subject a therapeutically effective amount of a compound
selected from the group consisting of:

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or a stereoisomer thereof, or a pharmaceutically acceptable salt of said compound or said stereoisomer.