US 12,083,093 B2
Composition for preventing or treating cellular senescence-related diseases comprising salinomycin as effective component
Jae-Ryong Kim, Daegu (KR); Eok-Cheon Kim, Wonju-si (KR); Kyong-Jin Jung, Daegu (KR); and You Lim Son, Daegu (KR)
Assigned to RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY, Gyeongsan-si (KR)
Appl. No. 17/413,088
Filed by RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY, Gyeongsan-si (KR)
PCT Filed Oct. 11, 2019, PCT No. PCT/KR2019/013373
§ 371(c)(1), (2) Date Jun. 11, 2021,
PCT Pub. No. WO2020/122393, PCT Pub. Date Jun. 18, 2020.
Claims priority of application No. 10-2018-0161044 (KR), filed on Dec. 13, 2018.
Prior Publication US 2022/0008377 A1, Jan. 13, 2022
Int. Cl. A61K 31/35 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 13/12 (2006.01); A61P 19/04 (2006.01); A61P 27/02 (2006.01)
CPC A61K 31/35 (2013.01) [A61P 9/10 (2018.01); A61P 11/00 (2018.01); A61P 13/12 (2018.01); A61P 19/04 (2018.01); A61P 27/02 (2018.01)] 6 Claims
OG exemplary drawing
 
1. A method for restoring function of a senescent cell to a normal cell comprising administering a pharmaceutical composition comprising salinomycin as an active ingredient to a subject in need of restoring function of the senescent cell to the normal cell,
wherein the senescent cell is selected from the group consisting of a fibroblast and a vascular endothelial cell, and
wherein a senescence is induced by drug treatment or subculture in the senescent cell.