US 12,082,930 B2
Methods, systems, and devices for calibration and optimization of glucose sensors and sensor output
Peter Ajemba, Canyon Country, CA (US); Keith Nogueira, Mission Hills, CA (US); Jeffrey Nishida, Redwood City, CA (US); and Andy Y. Tsai, Pasadena, CA (US)
Assigned to MEDTRONIC MINIMED, INC., Northridge, CA (US)
Filed by Medtronic MiniMed, Inc., Northridge, CA (US)
Filed on Sep. 7, 2022, as Appl. No. 17/939,067.
Application 17/939,067 is a division of application No. 16/117,466, filed on Aug. 30, 2018, granted, now 11,445,951, issued on Sep. 20, 2022.
Claims priority of provisional application 62/558,248, filed on Sep. 13, 2017.
Prior Publication US 2023/0000402 A1, Jan. 5, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/1495 (2006.01); A61B 5/00 (2006.01); A61B 5/0205 (2006.01); A61B 5/021 (2006.01); A61B 5/024 (2006.01); A61B 5/11 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01); A61B 5/1468 (2006.01); A61B 5/1486 (2006.01); G01N 27/02 (2006.01); G06N 5/022 (2023.01); G16H 20/17 (2018.01); G16H 40/40 (2018.01); G16H 50/30 (2018.01); G16H 50/70 (2018.01)
CPC A61B 5/1495 (2013.01) [A61B 5/14532 (2013.01); A61B 5/1468 (2013.01); A61B 5/14865 (2013.01); A61B 5/6849 (2013.01); A61B 5/686 (2013.01); G01N 27/026 (2013.01); G06N 5/022 (2013.01); G16H 20/17 (2018.01); G16H 40/40 (2018.01); G16H 50/30 (2018.01); G16H 50/70 (2018.01); A61B 5/0075 (2013.01); A61B 5/02055 (2013.01); A61B 5/021 (2013.01); A61B 5/024 (2013.01); A61B 5/1118 (2013.01); A61B 5/14546 (2013.01); A61B 5/1455 (2013.01); A61B 5/7203 (2013.01); A61B 5/7221 (2013.01); A61B 5/7267 (2013.01); A61B 5/742 (2013.01); A61B 2505/07 (2013.01); A61B 2560/0223 (2013.01); A61B 2560/0252 (2013.01); A61B 2560/0257 (2013.01); A61B 2562/028 (2013.01); A61B 2562/029 (2013.01); A61B 2562/164 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for external calibration of a glucose sensor used for measuring a level of glucose in a body of a user, the glucose sensor including physical sensor electronics, a microcontroller, and a working electrode, the method comprising:
accessing electrode current (Isig) signals for the working electrode, the Isig signals being measured by the physical sensor electronics;
accessing Electrochemical Impedance Spectroscopy (EIS) related data for the working electrode, the EIS-related data generated by an EIS procedure;
based on the Isig signals and the EIS-related data and a plurality of calibration-free sensor glucose (SG)-predictive models, calculating, by the microcontroller, a respective SG value for each of the SG-predictive models;
fusing, by the microcontroller, the respective SG values for the SG-predictive models to calculate a single, fused SG value;
calculating, by the microcontroller, a modification factor based on a value of a physiological calibration factor (PCF), a value of an environmental calibration factor (ECF), or both;
determining, by the microcontroller, whether the calculated modification factor is valid; and
in a case where the modification factor is determined to be valid:
calculating, by the microcontroller, a single, calibrated, fused SG value based on the modification factor and the single, fused SG value;
performing, by the microcontroller, error detection diagnostics on the calibrated, fused SG value to determine whether a correctable error exists in the calibrated, fused SG value;
in a case where it is determined that the correctable error exists, correcting, by the microcontroller, the correctable error; and
displaying a corrected, calibrated, fused SG value to the user,
wherein the PCF is based on status information of an activity level, a heart rate, a blood pressure, and a body temperature of the user.