US 12,082,907 B2
Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real-time
Michelle S. Bradbury, New York, NY (US); Ulrich Wiesner, Ithaca, NY (US); Richard J. C. Meester, Middenmeer (NL); Snehal G. Patel, New York, NY (US); Nadeem R. Abu-Rustum, Tenafly, NJ (US); and Mohan Pauliah, New York, NY (US)
Assigned to Memorial Sloan Kettering Cancer Center, New York, NY (US); Cornell University, Ithaca, NY (US); and Quest Medical Imaging B.V., Middenmeer (NL)
Filed by Memorial Sloan Kettering Cancer Center, New York, NY (US); Cornell University, Ithaca, NY (US); and Quest Medical Imaging B.V., Middenmeer (NL)
Filed on Feb. 11, 2020, as Appl. No. 16/787,112.
Application 16/787,112 is a division of application No. 14/588,066, filed on Dec. 31, 2014, granted, now 10,986,997.
Claims priority of provisional application 61/987,426, filed on May 1, 2014.
Claims priority of provisional application 61/922,619, filed on Dec. 31, 2013.
Prior Publication US 2020/0214571 A1, Jul. 9, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 1/00 (2006.01); A61B 1/04 (2006.01); A61B 1/045 (2006.01); A61B 1/05 (2006.01); A61B 1/06 (2006.01); A61B 1/07 (2006.01); A61B 1/313 (2006.01); A61B 6/03 (2006.01)
CPC A61B 5/0071 (2013.01) [A61B 1/00006 (2013.01); A61B 1/000094 (2022.02); A61B 1/000095 (2022.02); A61B 1/000096 (2022.02); A61B 1/0005 (2013.01); A61B 1/00096 (2013.01); A61B 1/00105 (2013.01); A61B 1/00186 (2013.01); A61B 1/00188 (2013.01); A61B 1/042 (2013.01); A61B 1/043 (2013.01); A61B 1/045 (2013.01); A61B 1/051 (2013.01); A61B 1/0646 (2013.01); A61B 1/0669 (2013.01); A61B 1/07 (2013.01); A61B 1/3132 (2013.01); A61B 5/0084 (2013.01); A61B 5/742 (2013.01); A61B 6/037 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A portable imaging system, comprising a portable imaging apparatus and a plurality of different fluorescent reporters that produce fluorescent light at two or more distinguishable wavelengths, wherein:
the portable imaging apparatus comprises:
a light source configured to deliver multiple excitation wavelengths of light to excite the plurality of different fluorescent reporters that produce fluorescent light at two or more distinguishable wavelengths, wherein the light source is configured to deliver an even distribution of light via a plurality of emission points disposed in a planar configuration around a single axis optical lens;
a prism configured to direct light received through a lens onto a plurality of spatially-separated detectors via at least three discrete optical pathways, such that said detectors can simultaneously measure, in real-time, different emitted fluorescent signals at the two or more distinguishable wavelengths; and
a processor configured to process signals corresponding to the detected fluorescent light at the two or more distinguishable wavelengths to provide images of fluorescence of the plurality of different fluorescent reporters within a subject;
and wherein each of the plurality of different fluorescent reporters comprises a silica nanoparticle.