US 12,082,905 B2
Treating epilepsy and other neurological disorders by targeting therapy to the endopiriform nucleus using ultra-high field magnetic resonance imaging
Thomas R. Henry, Minneapolis, MN (US); Gregory F. Molnar, Minneapolis, MN (US); Michael C. Park, Minneapolis, MN (US); and Pierre-Francois Van De Moortele, Minneapolis, MN (US)
Assigned to REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US)
Appl. No. 17/766,420
Filed by REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US)
PCT Filed Oct. 5, 2020, PCT No. PCT/US2020/054247
§ 371(c)(1), (2) Date Apr. 4, 2022,
PCT Pub. No. WO2021/067928, PCT Pub. Date Apr. 8, 2021.
Claims priority of provisional application 62/910,798, filed on Oct. 4, 2019.
Prior Publication US 2023/0190105 A1, Jun. 22, 2023
Int. Cl. A61B 5/00 (2006.01); A61N 1/36 (2006.01)
CPC A61B 5/0042 (2013.01) [A61B 5/0036 (2018.08); A61N 1/36064 (2013.01)] 27 Claims
OG exemplary drawing
 
1. A method for generating treatment plan data from images acquired using a magnetic resonance imaging (MRI) system, the method comprising:
(a) accessing with a computer system, magnetic resonance image data acquired from a subject using an ultra-high field MM system, wherein the magnetic resonance image data comprise T2-weighted images of the subject;
(b) localizing the subject's endopiriform nucleus (EPN) by using the computer system to analyze the T2-weighted images in the magnetic resonance image data, generating output as localized EPN data that indicate at least one of a spatial location and spatial extent of the subject's EPN;
(c) generating treatment plan data with the computer system using the localized EPN data, wherein the treatment plan data define a treatment delivery for delivering treatment to the subject's EPN.