US 12,082,863 B1
Pulsed field electroporation systems and methods
James H. Atkins, Jr., San Antonio, TX (US); John Ross Saunders, Edinburgh (GB); and Jetmir Palushi, Irvine, CA (US)
Assigned to Aventix Medical Inc., Irvine, CA (US)
Filed by Aventix Medical Inc., Irvine, CA (US)
Filed on Apr. 1, 2024, as Appl. No. 18/623,681.
Application 18/623,681 is a continuation of application No. 18/616,916, filed on Mar. 26, 2024, granted, now 12,042,202.
Application 18/623,681 is a continuation of application No. 18/613,827, filed on Mar. 22, 2024.
Claims priority of provisional application 63/536,339, filed on Sep. 1, 2023.
Claims priority of provisional application 63/504,510, filed on May 26, 2023.
Int. Cl. A61B 18/00 (2006.01)
CPC A61B 18/00 (2013.01) [A61B 2018/00077 (2013.01); A61B 2018/00327 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00708 (2013.01); A61B 2018/00714 (2013.01); A61B 2018/00732 (2013.01); A61B 2018/0075 (2013.01); A61B 2018/00761 (2013.01); A61B 2018/00767 (2013.01); A61B 2018/00982 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A method comprising:
mating a removable connector of a handheld pulsed field electroporation (PFE) tool to a PFE control console;
inserting the handheld PFE tool into a nasal passageway of a patient, the handheld PFE tool having a handle, an elongated shaft extending distally from the handle toward a bendable distal shaft portion, and a bulbous treatment tip extending distally from the bendable distal shaft portion and having a PFE electrode configured to deliver PFE pulses to nasal tissue in the nasal passageway of the patient adjacent to the bulbous treatment tip, the bulbous treatment tip having a maximum lateral width of less than 5 mm; and
outputting, from the PFE electrode, a pulsed field according to a predefined pattern of pulses having a voltage within a range from 850 V to 10,000 V and a pulse duration of 0.05 microseconds (μs) to 3 μs to induce irreversible electroporation in the nasal tissue,
wherein outputting the pulsed field comprises outputting, by a PFE generator of the PFE control console, the pulsed field according to the predefined pattern of pulses via the PFE electrode; and
activating a neurostimulation mode so that the PFE generator delivers the pulsed field to include a sequence of bursts of PFE pulses via the PFE electrode to provide neurostimulation to one or more nerves proximate to the bulbous treatment tip.